Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase
| Autor: | Martin Best-Belpomme, Nicole Defer, Jacques Hanoune |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Gene isoform
Regulation of gene expression Cell type medicine.medical_specialty Calmodulin biology Physiology Myocardium Brain Transfection Kidney Gene Expression Regulation Enzymologic Cell biology Isoenzymes Adenylyl cyclase chemistry.chemical_compound Endocrinology chemistry Internal medicine biology.protein medicine Extracellular Animals Receptor Adenylyl Cyclases |
| Zdroj: | American Journal of Physiology-Renal Physiology. 279:F400-F416 |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.2000.279.3.f400 |
| Popis: | The present review focuses on the potential physiological regulations involving different isoforms of adenylyl cyclase (AC), the enzymatic activity responsible for the synthesis of cAMP from ATP. Depending on the properties and the relative level of the isoforms expressed in a tissue or a cell type at a specific time, extracellular signals received by the G protein-coupled receptors can be differently integrated. We report here on various aspects of such regulations, emphasizing the role of Ca2+/calmodulin in activating AC1 and AC8 in the central nervous system, the potential inhibitory effect of Ca2+on AC5 and AC6, and the changes in the expression pattern of the isoforms during development. A particular emphasis is given to the role of cAMP during drug dependence. Present experimental limitations are also underlined (pitfalls in the interpretation of cellular transfection, scarcity of the invalidation models, and so on). |
| Databáze: | OpenAIRE |
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