Prenatal pregabalin is associated with sex‐dependent alterations in some behavioral parameters in valproic acid‐induced autism in rat offspring
| Autor: | Gholamreza Sepehri, Hamideh Bashiri, Manzumeh Shamsi Meymandi, Amirhossein Moslemizadeh, SeyyedSajjad Vakili Shahrbabaki |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pain Threshold Elevated plus maze medicine.medical_specialty Offspring Pregabalin Anxiety Motor Activity Choice Behavior Open field 03 medical and health sciences Sex Factors 0302 clinical medicine Developmental Neuroscience Pregnancy Internal medicine Threshold of pain Animals Medicine Autistic Disorder Hot plate test 030304 developmental biology Sex Characteristics 0303 health sciences Valproic Acid Behavior Animal business.industry Rats Disease Models Animal Endocrinology Prenatal Exposure Delayed Effects Gestation Female lipids (amino acids peptides and proteins) business 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | International Journal of Developmental Neuroscience. 80:500-511 |
| ISSN: | 1873-474X 0736-5748 |
| DOI: | 10.1002/jdn.10046 |
| Popis: | This study was performed to evaluate the effects of prenatal exposure to pregabalin (PGB) on behavioral changes of rat offspring in an animal model of valproic acid (VPA)-induced autism-like symptoms. Pregnant rats received VPA (600 mg/kg/i.p.) once at 12.5 gestational days for autism-like symptom induction in offspring. After the delivery single male and single female offspring from each mother were randomly selected for behavioral test (anxiety, pain response, pleasure, and motor function) at 60th day adulthood (n = 7). Offspring received prenatal PGB (15 & 30 mg/kg/i.p.) during gestational days 9.5 to 15.5 either alone or in combination with VPA (PGB15, PGB30, PGB15 + VPA, and PGB30 + VPA). Control offspring received normal saline during the same period. The result showed that prenatal VPA exposure was associated with autism-like behaviors in rat offspring. PGB treatment during the gestational period revealed significant reduction in sucrose preference test and anxiety in elevated plus maze and open field test in offspring. Also, PGB treatments exhibited a dose-dependent increase in pain threshold in prenatally VPA exposed rats in tail-flick and hot plate test. Also, there was a sex-related significant impairment in motor function in beam balance and open field test, and male rats were affected more than females. However, no significant sex differences in sucrose preference and pain sensitivity were observed in prenatal PGB-treated rat offspring. In conclusion, prenatal exposure to VPA increased the risk of autism-like behaviors in the offspring rats, and PGB treatment during the gestational period was associated with some beneficial effects, including anxiety reduction and motor impairment in autism-like symptoms in rat offspring. |
| Databáze: | OpenAIRE |
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