The First Korean Case of Disseminated Mycetoma Caused by Nocardia pseudobrasiliensis in a Patient on Long-Term Corticosteroid Therapy for the Treatment of Microscopic Polyangiitis
| Autor: | Chang Ahn Seol, Yong Pil Chong, Duck Hee Kim, Misuk Ji, Mi Na Kim, Heungsup Sung |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.drug_class
hsp65 Clinical Biochemistry Antibiotics Microscopic Polyangiitis Case Report Nocardia Microbiology Asian People Bacterial Proteins Adrenal Cortex Hormones RNA Ribosomal 16S Ampicillin Republic of Korea medicine Corticosteroids Humans Skin Scalp integumentary system biology Nocardia brasiliensis Biochemistry (medical) Nocardiosis Sequence Analysis DNA General Medicine Sulbactam Middle Aged Amoxicillin bacterial infections and mycoses biology.organism_classification medicine.disease Clinical Microbiology Mycetoma Female Microscopic polyangiitis Nocardia pseudobrasiliensis 16S ribosomal RNA medicine.drug |
| Zdroj: | Annals of Laboratory Medicine |
| ISSN: | 2234-3814 2234-3806 |
| Popis: | Nocardia pseudobrasiliensis is predominantly associated with invasive infections in immunocompromised patients. We report a case of disseminated mycetoma caused by N. pseudobrasiliensis in a 57-yr-old woman with microscopic polyangiitis, who was treated for 3 months with corticosteroids. The same organism was isolated from mycetoma cultures on the patient's scalp, right arm, and right leg. The phenotypic characteristics of the isolate were consistent with both Nocardia brasiliensis and N. pseudobrasiliensis, i.e., catalase and urease positivity, hydrolysis of esculin, gelatin, casein, hypoxanthine, and tyrosine, but no hydrolysis of xanthine. The isolate was identified as N. pseudobrasiliensis based on 16S rRNA and hsp65 gene sequencing. The patient was treated for 5 days with intravenous ampicillin/sulbactam, at which time both the mycetomas and fever had subsided and discharged on amoxicillin/clavulanate. This case highlights a very rare presentation of mainly cutaneous mycetoma caused by N. pseudobrasiliensis. This is the first reported case of N. pseudobrasiliensis infection in Korea. |
| Databáze: | OpenAIRE |
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