Pleuropulmonary involvement in patients with systemic lupus erythematosus from a Latin American inception cohort (GLADEL)
| Autor: | J C Tavares Brenol, Francisco Caeiro, G A Reyes Llerena, E M Acevedo Vásquez, M H Esteva Spinetti, Luis H. Silveira, M J Sauza del Pozo, A Iglesias Gamarra, B A Pons-Estel, J. Alfaro Lozano, Leonor A Barile-Fabris, Alejandro Alvarellos, L T Lavras Costallat, Daniel Wojdyla, A C de O e Silva, M J Haye Salinas, Gloria Vásquez, Hugo R. Scherbarth, Verónica Saurit, Graciela S. Alarcón, Oscar Neira |
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| Rok vydání: | 2017 |
| Předmět: |
Lung Diseases
Adult Male medicine.medical_specialty Heart disease Epidemiology Disease Severity of Illness Index Cohort Studies 03 medical and health sciences pulmonary systemic lupus erythematosus 0302 clinical medicine Rheumatology Internal medicine Lower respiratory tract infection Severity of illness Lupus Erythematosus Systemic/complications/mortality medicine Lupus Erythematosus Systemic Humans Pleurisy Respiratory Tract Infections Pleurisy/etiology purl.org/pe-repo/ocde/ford#3.02.17 [https] 030203 arthritis & rheumatology business.industry Lung Diseases/etiology medicine.disease Respiratory Tract Infections/etiology medicine.anatomical_structure 030228 respiratory system Female business Respiratory tract Cohort study |
| Zdroj: | Lupus. 26:1368-1377 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203317699284 |
| Popis: | Objectives The objectives of this study were to examine the demographic and clinical features associated with the occurrence of pleuropulmonary manifestations, the predictive factors of their occurrence and their impact on mortality in systemic lupus erythematosus (SLE) patients. Materials and methods The association of pleuropulmonary manifestations with demographic and clinical features, the predictive factors of their occurrence and their impact on mortality were examined in GLADEL patients by appropriate univariable and multivariable analyses. Results At least one pleuropulmonary manifestation occurred in 421 of the 1480 SLE patients (28.4%), pleurisy being the most frequent (24.0%). Age at SLE onset ≥30 years (OR 1.42; 95% CI 1.10–1.83), the presence of lower respiratory tract infection (OR 3.19; 95% CI 2.05–4.96), non-ischemic heart disease (OR 3.17; 95% CI 2.41–4.18), ischemic heart disease (OR 3.39; 95% CI 2.08–5.54), systemic (OR 2.00; 95% CI 1.37–2.91), ocular (OR 1.58; 95% CI 1.16–2.14) and renal manifestations (OR 1.44; 95% CI 1.09–1.83) were associated with pleuropulmonary manifestations, whereas cutaneous manifestations were negatively associated (OR 0.47; 95% CI 0.29–0.76). Non-ischemic heart disease (HR 2.24; 95% CI 1.63–3.09), SDI scores ≥1 (OR 1.54; 95% CI 1.10–2.17) and anti-La antibody positivity (OR 2.51; 95% CI 1.39–4.57) independently predicted their subsequent occurrence. Cutaneous manifestations were protective of the subsequent occurrence of pleuropulmonary manifestations (HR 0.62; 95% CI 0.43–0.90). Pleuropulmonary manifestations independently contributed a decreased survival (HR: 2.79 95% CI 1.80–4.31). Conclusion Pleuropulmonary manifestations are frequent in SLE, particularly pleuritis. Older age, respiratory tract infection, cardiac, systemic and renal involvement were associated with them, whereas cutaneous manifestations were negatively associated. Cardiac compromise, SDI scores ≥1 and anti-La positivity at disease onset were predictive of their subsequent occurrence, whereas cutaneous manifestations were protective. They independently contributed to a decreased survival in these patients. |
| Databáze: | OpenAIRE |
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