Bilateral low-frequency repetitive transcranial magnetic stimulation of the auditory cortex in tinnitus patients is not effective: a randomised controlled trial
| Autor: | Marlien E F Niesten, Gijsbert A. van Zanten, Carlijn E. L. Hoekstra, Sebastiaan F.W. Neggers, Huib Versnel |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Neuronavigation Physiology medicine.medical_treatment Audiology Placebo Auditory cortex law.invention Speech and Hearing Tinnitus Randomized controlled trial Double-Blind Method law otorhinolaryngologic diseases medicine Humans Treatment Failure Deep transcranial magnetic stimulation Aged Auditory Cortex Cross-Over Studies business.industry Middle Aged equipment and supplies Placebo Effect Crossover study Transcranial Magnetic Stimulation Sensory Systems Transcranial magnetic stimulation Otorhinolaryngology Chronic Disease Physical therapy Female medicine.symptom business human activities Follow-Up Studies |
| Zdroj: | Audiologyneuro-otology. 18(6) |
| ISSN: | 1421-9700 |
| Popis: | Background: Although some therapies may be beneficial for some patients in reducing tinnitus, there is no curative therapy. Repetitive transcranial magnetic stimulation (rTMS) has been applied as a treatment for chronic tinnitus, but the effect remains controversial. Material and Methods: Fifty patients were treated with rTMS or placebo. Treatment consisted of 2,000 TMS pulses on each auditory cortex, at a rate of 1 Hz and an intensity of 110% of the individual motor threshold, on 5 consecutive days. rTMS and placebo effects were evaluated directly after treatment, after 1 week, and after 1, 3 and 6 months. Primary outcome was the Tinnitus Questionnaire (TQ). Secondary outcomes were the Tinnitus Handicap Inventory (THI) and a visual analogue scale. Results: At none of the follow-up evaluation moments a significant difference between rTMS and placebo was observed with respect to changes in TQ or THI scores relative to pretreatment scores. Multilevel modelling (MLM) analyses did not show a global treatment effect either. Patients with a higher degree of burden showed slightly greater improvement after rTMS (only significant on the THI with MLM analyses). Conclusion: Bilateral low-frequency rTMS of the auditory cortex was not effective in treating tinnitus. |
| Databáze: | OpenAIRE |
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