CYFRA 21 -1: An Indicator of Survival and Therapeutic Effect in Lung Cancer
| Autor: | Takeyuki Makimoto, Kazuhiro Ezawa, Satoshi Tsuchiya, Ryusei Saito, Hidehiko Nakano, Atsushi Takise, Masaki Mori, Shinichi Ishihara, Ichiro Naruse, Hideki Hoshino, Taisuke Nomoto, Naoto Fueki, Koichi Minato, Yoshikazu Takei |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Lung Neoplasms Gastroenterology Cytokeratin Antigens Neoplasm Predictive Value of Tests Internal medicine Biomarkers Tumor medicine Carcinoma Humans CYFRA 21-1 Lung cancer Survival analysis Aged Tumor marker Keratin-19 business.industry Respiratory disease General Medicine Middle Aged medicine.disease Survival Analysis Treatment Outcome Oncology Keratins Adenocarcinoma Female business |
| Zdroj: | Oncology. 54:43-47 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | CYFRA 21-1 is a new tumor marker using two different monoclonal antibodies which recognize the divergent epitope on the N- or C-terminal region of domain 2 of cytokeratin 19 fragment, respectively. In this study, we investigated the relationship between levels of CYFRA 21-1 and survival duration, as well as the efficacy of chemotherapy associated with changes in CYFRA 21-1. Serum samples were obtained from 87 patients with nonoperable lung cancer (35 cases with squamous-cell carcinoma, 33 with adenocarcinoma, 3 with large-cell carcinoma, and 16 with small-cell carcinoma). The cutoff point was set at 3.5 ng/ml. In a CYFRA 21-1 assay, significantly more patients with squamous-cell carcinoma and adenocarcinoma were positive compared to patients with small-cell and large-cell carcinomas (p = 0.0017). Following chemotherapy, blood levels of CYFRA 21-1 decreased significantly in responders versus nonresponders (p = 0.0246). A significant correlation was noted between survival periods and pretreatment levels of CYFRA 21-1 (p = 0.0036). The present study suggests that CYFRA 21-1 might be useful as a possible indicator of survival and therapeutic effect for lung cancer. |
| Databáze: | OpenAIRE |
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