Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome
| Autor: | Joseph K. Salama, Karthik Vishwanath, Nimmi Ramanujam, Alaattin Erkanli, James R. Oleson, Fangyao Hu, David M. Brizel, Walter T. Lee, Bercedis Peterson, Mark W. Dewhirst |
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| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
Metabolic Clearance Rate medicine.medical_treatment chemistry.chemical_element 01 natural sciences Oxygen Article 010309 optics Hemoglobins Mice 03 medical and health sciences 0302 clinical medicine Cell Line Tumor 0103 physical sciences Animals Humans Medicine Radiology Nuclear Medicine and imaging Irradiation Oxygen saturation (medicine) Radiation Squamous Cell Carcinoma of Head and Neck business.industry Head and neck cancer Dose-Response Relationship Radiation Radiotherapy Dosage Oxygenation Tumor Oxygenation medicine.disease Radiation therapy Kinetics Treatment Outcome Oncology chemistry Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Tumor Hypoxia Female Dose Fractionation Radiation Radiotherapy Conformal Nuclear medicine business Perfusion Blood Flow Velocity |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 96:462-469 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2016.06.007 |
| Popis: | Purpose To test whether oxygenation kinetics correlate with the likelihood for local tumor control after fractionated radiation therapy. Methods and Materials We used diffuse reflectance spectroscopy to noninvasively measure tumor vascular oxygenation and total hemoglobin concentration associated with radiation therapy of 5 daily fractions (7.5, 9, or 13.5 Gy/d) in FaDu xenografts. Spectroscopy measurements were obtained immediately before each daily radiation fraction and during the week after radiation therapy. Oxygen saturation and total hemoglobin concentration were computed using an inverse Monte Carlo model. Results First, oxygenation kinetics during and after radiation therapy, but before tumor volumes changed, were associated with local tumor control. Locally controlled tumors exhibited significantly faster increases in oxygenation after radiation therapy (days 12-15) compared with tumors that recurred locally. Second, within the group of tumors that recurred, faster increases in oxygenation during radiation therapy (day 3-5 interval) were correlated with earlier recurrence times. An area of 0.74 under the receiver operating characteristic curve was achieved when classifying the local control tumors from all irradiated tumors using the oxygen kinetics with a logistic regression model. Third, the rate of increase in oxygenation was radiation dose dependent. Radiation doses ≤9.5 Gy/d did not initiate an increase in oxygenation, whereas 13.5 Gy/d triggered significant increases in oxygenation during and after radiation therapy. Conclusions Additional confirmation is required in other tumor models, but these results suggest that monitoring tumor oxygenation kinetics could aid in the prediction of local tumor control after radiation therapy. |
| Databáze: | OpenAIRE |
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