Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra)

Autor: Fabrizio Grandi, Mónica Aristizabal-Arbelaez, Julian Mejía-Restrepo, Francisco Pedraza-Ordóñez, Mauricio Montoya-Flórez
Přispěvatelé: Univ Caldas, Universidade Estadual Paulista (Unesp), Natl Assoc Small Anim Clinicians Anclivepa
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
BMC Veterinary Research, Vol 8, Iss 1, p 97 (2012)
BMC Veterinary Research
Popis: Made available in DSpace on 2013-08-28T14:11:55Z (GMT). No. of bitstreams: 1 WOS000312219200001.pdf: 1969636 bytes, checksum: c545ec086337e74081323d448ee8f9bb (MD5) Made available in DSpace on 2013-09-30T18:22:55Z (GMT). No. of bitstreams: 2 WOS000312219200001.pdf: 1969636 bytes, checksum: c545ec086337e74081323d448ee8f9bb (MD5) WOS000312219200001.pdf.txt: 31384 bytes, checksum: ee59d0a14d643ad2c6a129c94b8f08d6 (MD5) Previous issue date: 2012-06-29 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:37:38Z No. of bitstreams: 2 WOS000312219200001.pdf: 1969636 bytes, checksum: c545ec086337e74081323d448ee8f9bb (MD5) WOS000312219200001.pdf.txt: 31384 bytes, checksum: ee59d0a14d643ad2c6a129c94b8f08d6 (MD5) Made available in DSpace on 2014-05-20T13:37:38Z (GMT). No. of bitstreams: 2 WOS000312219200001.pdf: 1969636 bytes, checksum: c545ec086337e74081323d448ee8f9bb (MD5) WOS000312219200001.pdf.txt: 31384 bytes, checksum: ee59d0a14d643ad2c6a129c94b8f08d6 (MD5) Previous issue date: 2012-06-29 Background: Spontaneous gastrointestinal neoplasms in non-human primates are commonly seen in aged individuals. Due to genetic similarities between human and non-human primates, scientists have shown increasing interest in terms of comparative oncology studies.Case presentation: The present study is related to a case of an intestinal leiomyoma in a black crested macaque (Macaca nigra), kept on captivity by Mateca a Zoo, Pereira City, Colombia. The animal had abdominal distension, anorexia, vomiting, diarrhea and behavioral changes. Clinical examination showed an increased volume in the upper right abdominal quadrant caused by a neoplastic mass. The patient died during the surgical procedure. Necropsy revealed several small nodules in the peritoneum with adhesion to different portions of the small and large intestines, liver, stomach and diaphragm. Tissue samples were collected, routinely processed and stained by H&E. Microscopic examination revealed a mesenchymal tumor limited to tunica muscularis, resembling normal smooth muscle cells. Neoplastic cells were positive for alpha-smooth muscle actin and vimentin, and negative for cytokeratin AE1/AE3 by immunohistochemistry. Those morphological and immunohistochemical findings allowed to diagnose the intestinal leiomyoma referred above.Conclusion: Neoplastic diseases in primates have multifaceted causes. Their manifestations are understudied, leading to a greater difficulty in detection and measurement of the real impact provides by this disease. Univ Caldas, Fac Agr Sci, Vet Pathol Res Grp, Manizales, Colombia Univ Estadual Paulista, UNESP, Dept Vet Clin, Lab Invest & Comparat Pathol, Botucatu, SP, Brazil Univ Caldas, Anim Hlth Dept, Manizales, Colombia Univ Estadual Paulista, UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil Natl Assoc Small Anim Clinicians Anclivepa, Vet Serv, Publ Vet Hosp, Dept Diagnost Pathol, São Paulo, Brazil Univ Estadual Paulista, UNESP, Dept Vet Clin, Lab Invest & Comparat Pathol, Botucatu, SP, Brazil Univ Estadual Paulista, UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil
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