Synthesis, Characterization, and Antimicrobial Evaluation of Random Poly(ester-Carbonate)s Bearing Pendant Primary Amine in the Main Chain
| Autor: | Qingshan Shi, Xiaobao Xie, Ting-Li Sun, Sujuan Li, Jing Feng, Peng Dong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
antimicrobial activity
Polymers and Plastics primary amine General Chemistry medicine.disease_cause Medicinal chemistry Ring-opening polymerization Article lcsh:QD241-441 chemistry.chemical_compound Minimum inhibitory concentration cyclic carbonate chemistry lcsh:Organic chemistry low hemolysis and cytotoxicity Staphylococcus aureus Benzyl alcohol poly(ester-carbonate)s Amphiphile Copolymer medicine Amine gas treating Caprolactone |
| Zdroj: | Polymers Volume 12 Issue 11 Polymers, Vol 12, Iss 2640, p 2640 (2020) |
| ISSN: | 2073-4360 |
| DOI: | 10.3390/polym12112640 |
| Popis: | Starting from primary amine bearing cyclic carbonate tert-butyl-(2-oxo-1,3-dioxan-5-yl) carbamate (TBODC) and caprolactone (CL), amphiphilic poly(caprolactone-ran-amino trimethyl carbonate)s (P(CL-ran-ATC)s) random copolymers with controlled molecular weight and composition were synthesized via ring opening polymerization (ROP) and deprotection, using stannous octoate (Sn(Oct)2) as catalyst and benzyl alcohol (BnOH) as initiator. Therefore, hydrophilic/lipophilic ratio (HLR) of the P(CL-ran-ATC)s copolymers can be finely adjusted by the feed ratio of TBODC and CL. The antimicrobial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) of P(CL-ran-ATC)s were proportional to HLR, and P(CL-ran-ATC)s presented more vigorous bactericidal activity towards S. aureus. The minimum inhibitory concentration (MIC) values of P(CL-ran-ATC 50.9%) are 2000 &mu g mL&minus 1 and 3000 &mu 1 for S. aureus and E. coli. While P(CL-ran-ATC 50.9%) exhibited deficient hemolytic activity as 1.41%. In addition, the P(CL-ran-ATC)s showed extremely low cytotoxicity towards fibroblast L929 cells. |
| Databáze: | OpenAIRE |
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