Bactericidal properties of straight-chained alkyltrimethylammonium bromides in a simple emulsion system

Autor:	George Carr Hoss, Allen I. Dines, Blaze T. Palermo, Thomas Laurence Welsh
Rok vydání:	1967
Předmět:	Bromides Bacteria Staphylococcus Cetrimide Pharmaceutical Science Alcohol Dilution Quaternary Ammonium Compounds Solutions chemistry.chemical_compound chemistry Alcohols Alkanes Pseudomonas aeruginosa Emulsion Organic chemistry Emulsions
Zdroj:	Journal of Pharmaceutical Sciences. 56:1464-1467
ISSN:	0022-3549
DOI:	10.1002/jps.2600561118
Popis:	The individual constituents of the potent bactericidal agent cetrimide B.P. are among those alkyltrimethylammonium bromides (C 8 through C 18 ). which have been synthesized by classical methods. Each of these quaternary compounds was then emulsified with six (C 8 through C 18 ) fatty alcohols. The bactericidal properties of these emulsions are compared by the critical killing dilution method. When emulsified, only the C 12 and C 14 quaternary compounds exhibited any appreciable bactericidal action. All of the quaternary compounds in the series are inactivated when emulsified with myristyl alcohol.
Databáze:	OpenAIRE
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