Sweeping lymph node micrometastases off their feet: an engineered model to evaluate natural killer cell mediated therapeutic intervention of circulating tumor cells that disseminate to the lymph nodes
| Autor: | Michael R. King, Matthew J. McGuire, Siddarth Chandrasekaran |
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| Rok vydání: | 2013 |
| Předmět: |
Silicon
Biomedical Engineering Bioengineering Apoptosis Biochemistry Models Biological Metastasis Natural killer cell TNF-Related Apoptosis-Inducing Ligand Circulating tumor cell CD57 Antigens Cell Line Tumor medicine Lymph node stromal cell Humans Lymph node Microbubbles business.industry Antibodies Monoclonal General Chemistry medicine.disease Neoplastic Cells Circulating Primary tumor Killer Cells Natural medicine.anatomical_structure Lymphatic system Neoplasm Micrometastasis Lymphatic Metastasis Immunology Liposomes Cancer research Lymph Lymph Nodes business Antibodies Immobilized |
| Zdroj: | Lab on a chip. 14(1) |
| ISSN: | 1473-0189 |
| Popis: | Approximately 90% of cancer related deaths are due to metastasis. Cells from the primary tumor can metastasize through either the vascular or lymphatic circulation. Cancer cells in circulation are called circulating tumor cells (CTCs) and it has been shown that bone marrow is a niche for homing of blood borne CTCs from several epithelial tumors. Cancer cells found in bone marrow are termed disseminated tumor cells (DTCs). Likewise, CTCs in the lymphatic circulation are more often seeded in the sentinel lymph nodes (SLN) that drain the tumor. Micrometastases ( |
| Databáze: | OpenAIRE |
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