Association between early methylmercury exposure and functional health among residents of the Shiranui Sea communities in Japan
Autor: | Kayo Ushijima, Sadami Maruyama, Shiro Tanaka, Woncheol Sung, Mika Tanaka, Yoshito Mukai, Kenji Tamura, Minoru Kawakita |
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Rok vydání: | 2012 |
Předmět: |
Gerontology
Adult Male Activities of daily living Minamata disease Health Toxicology and Mutagenesis Food Contamination Functional health chemistry.chemical_compound Japan Activities of Daily Living medicine Odds Ratio Prevalence Humans Methylmercury Mercury Poisoning Nervous System Aged Dose-Response Relationship Drug business.industry Public Health Environmental and Occupational Health General Medicine Environmental Exposure Methylmercury Compounds Middle Aged medicine.disease Pollution Cross-Sectional Studies Logistic Models chemistry Seafood Socioeconomic Factors Female business Water Pollutants Chemical |
Zdroj: | International journal of environmental health research. 22(5) |
ISSN: | 1369-1619 |
Popis: | The objective of this study was to evaluate the effect of estimated historical methylmercury exposure on the functional health of residents living in the Shiranui Sea communities in Japan. Functional health was measured by self-reported activities of daily living (ADL). Study areas were categorized into high, medium and low methylmercury exposure areas according to their location or distance from the Shiranui Sea. We estimated the adjusted prevalence odds ratios of impaired ADL in relation to exposure using a logistic regression model. Compared with residents in the low-exposure area, residents in the high-exposure area were significantly associated with a higher prevalence odds ratio (OR) for impaired ADL after adjustment for confounding factors (adjusted ORs = 2.8, 95% CI: 1.3-6.2). These results showed strong dose-response relationships (p for trend = 0.0050). Our findings suggest that historical methylmercury exposure might cause functional impairment in later in life depending on the exposure level. |
Databáze: | OpenAIRE |
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