In HIV type 1-infected children cytotoxic T lymphocyte responses are associated with greater reduction of viremia under antiretroviral therapy

Autor: Jérôme Le Chenadec, Nassima Bellal, Marianne Burgard, Florence Buseyne, Marie-Jeanne Mayaux, Christine Rouzioux, Stéphane Blanche, Yves Rivière
Přispěvatelé: Immunopathologie Virale, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Epidémiologie, Démographie et Sciences Sociales: santé reproductive, sexualité et infection à VIH (Inserm U569), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d'études démographiques (INED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant, Université Paris Descartes - Paris 5 (UPD5), Fédération de Pédiatrie, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut national d'études démographiques (INED), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Epidémiologie, Démographie et Sciences Sociales: santé reproductive, sexualité et infection à VIH ( Inserm U569 ), Epidémiologie, sciences sociales, santé publique ( IFR 69 ), Université Panthéon-Sorbonne ( UP1 ) -Université Paris-Sud - Paris 11 ( UP11 ) -École des hautes études en sciences sociales ( EHESS ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Panthéon-Sorbonne ( UP1 ) -Université Paris-Sud - Paris 11 ( UP11 ) -École des hautes études en sciences sociales ( EHESS ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut national d'études démographiques ( INED ), Université Paris Descartes - Paris 5 ( UPD5 ), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2005
Předmět:
MESH: CD4 Lymphocyte Count
MESH : Viral Load
MESH : Child
Preschool
MESH: HIV-1
0302 clinical medicine
MESH : Cross-Sectional Studies
MESH : Child
MESH: Child
Cytotoxic T cell
030212 general & internal medicine
Longitudinal Studies
MESH: Anti-HIV Agents
MESH: Longitudinal Studies
Child
MESH : Longitudinal Studies
0303 health sciences
MESH : Acquired Immunodeficiency Syndrome
MESH : Infant
Viral Load
MESH: Infant
3. Good health
Infectious Diseases
Child
Preschool
Drug Therapy
Combination
Viral disease
MESH : Viremia
MESH: Viral Load
Viral load
MESH : HIV-1
Combination therapy
Adolescent
Anti-HIV Agents
Immunology
Viremia
Biology
MESH : T-Lymphocytes
Cytotoxic
03 medical and health sciences
Immune system
MESH: Cross-Sectional Studies
Virology
MESH : Adolescent
medicine
MESH : CD4 Lymphocyte Count
Humans
MESH: Viremia
030304 developmental biology
MESH: Acquired Immunodeficiency Syndrome
MESH: Adolescent
Acquired Immunodeficiency Syndrome
MESH: Humans
MESH : Anti-HIV Agents
MESH : Drug Therapy
Combination
MESH : Humans
MESH: Child
Preschool
Infant
medicine.disease
CD4 Lymphocyte Count
CTL
MESH: Drug Therapy
Combination
Cross-Sectional Studies
HIV-1
MESH: T-Lymphocytes
Cytotoxic
CD8
T-Lymphocytes
Cytotoxic
Zdroj: AIDS Research and Human Retroviruses
AIDS Research and Human Retroviruses, Mary Ann Liebert, 2005, 21 (8), pp.719-27. ⟨10.1089/aid.2005.21.719⟩
AIDS Research and Human Retroviruses, Mary Ann Liebert, 2005, 21 (8), pp.719-27. 〈10.1089/aid.2005.21.719〉
AIDS Research and Human Retroviruses, 2005, 21 (8), pp.719-27. ⟨10.1089/aid.2005.21.719⟩
ISSN: 0889-2229
Popis: The evolution of the HIV-specific CD8+ T cell response in patients receiving potent combination therapy has been well documented in adult patients. However, no study reported whether baseline HIV-specific CD8+ T cell response is linked to treatment outcome. The aims of this study were to investigate both the impact of baseline memory cytotoxic T lymphocytes (CTL) on treatment outcome and the effect of potent therapy on memory HIV-specific CTL in HIV-1-infected pediatric patients. The study group comprised 30 children who started a first-line combination treatment including at least three drugs from two different classes and were longitudinally followed during treatment. Their memory HIV-specific responses were measured at baseline and during treatment, as well as their plasma viremia and CD4+ levels. The intensity of memory Gag-specific CTL and the breadth of the CTL response at the beginning of treatment were significantly correlated with lower plasma viral load during treatment, independently of baseline plasma viral load, CD4+ counts, and age. Children with partially controlled viral replication had enhanced Gag-specific CTL compared to their baseline value. This improvement of antiviral responses during treatment was not observed when viral replication was either fully suppressed or uncontrolled. In conclusion, our results show that higher baseline HIV-specific CTL are linked to lower viremia under combination therapy. This result adds further support to the hypothesis that cooperation between the antiviral immune response and antiviral drugs could be helpful for therapeutic management of HIV-infected patients.
Databáze: OpenAIRE
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