Long-term survival outcomes of pineal region gliomas
Autor: | Szymon Baluszek, Julio C. Resendiz-Nieves, Sajjad Muhammad, Juha Hernesniemi, Joham Choque-Velasquez, Roberto Colasanti, Behnam Rezai Jahromi |
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Přispěvatelé: | Clinicum, HUS Neurocenter, Neurokirurgian yksikkö, University of Helsinki, Helsinki University Hospital Area, Department of Neurosciences |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Cancer Research Neurology Pineal region Disease Pineal Gland 3124 Neurology and psychiatry 0302 clinical medicine Pineal region gliomas Medicine BRAIN Child extent of surgical resection Brain Neoplasms Glioma Middle Aged Prognosis TUMORS 3. Good health Oncology 030220 oncology & carcinogenesis Child Preschool Female Radiology long-term outcomes survival rate Adult medicine.medical_specialty Adolescent Extent of resection CLASSIFICATION 03 medical and health sciences Young Adult Long term survival MANAGEMENT Humans Survival rate Retrospective Studies business.industry CENTRAL-NERVOUS-SYSTEM 3112 Neurosciences 3126 Surgery anesthesiology intensive care radiology medicine.disease Clinical Study EXPERIENCE Histopathology Neurology (clinical) business 030217 neurology & neurosurgery Follow-Up Studies |
Zdroj: | Journal of Neuro-Oncology |
ISSN: | 1573-7373 0167-594X |
Popis: | PurposeSurgical series of pineal region gliomas are rarely available. Whereas it is a general assumption that the extent of surgical resection correlates with survival outcomes of intracranial gliomas; the impact of the microsurgical resection on the long-term outcomes of pineal gliomas has been questioned. We present a surgical series of pineal region gliomas with focus on the survival outcome analysis.Methods17 histologically confirmed pineal region glioma patients classified as diffuse and non-diffuse gliomas were retrospectively analyzed. A detailed description of the series was followed by regression models to identify predictors of clinical outcomes. Uni- a multivariate survival analysis was performed to determine independent predictors of mortality.ResultsAlthough the number of treated patients was small, only WHO grade histopathology remained significant (p = 0.02) after multivariate survival analysis with extent of resection, age, tumor volume, and preoperative functional status. The extent of the surgical resection did not correlate with the disease survival rates of non-diffuse (p = 1), diffuse (p = 0.2), nor all gliomas (p = 0.6). 15 of 17 patients underwent gross total (nine patients) or subtotal resection. The preoperative functional status of the patients showed overall improvement on the immediate (p ConclusionThe extent of the surgical resection does not seem to significantly impact on the survival outcomes of pineal region gliomas. Thus, genotype and molecular features may essentially affect the outcome. Further research on the field is required. |
Databáze: | OpenAIRE |
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