Long-term survival outcomes of pineal region gliomas

Autor: Szymon Baluszek, Julio C. Resendiz-Nieves, Sajjad Muhammad, Juha Hernesniemi, Joham Choque-Velasquez, Roberto Colasanti, Behnam Rezai Jahromi
Přispěvatelé: Clinicum, HUS Neurocenter, Neurokirurgian yksikkö, University of Helsinki, Helsinki University Hospital Area, Department of Neurosciences
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Cancer Research
Neurology
Pineal region
Disease
Pineal Gland
3124 Neurology and psychiatry
0302 clinical medicine
Pineal region gliomas
Medicine
BRAIN
Child
extent of surgical resection
Brain Neoplasms
Glioma
Middle Aged
Prognosis
TUMORS
3. Good health
Oncology
030220 oncology & carcinogenesis
Child
Preschool
Female
Radiology
long-term outcomes
survival rate
Adult
medicine.medical_specialty
Adolescent
Extent of resection
CLASSIFICATION
03 medical and health sciences
Young Adult
Long term survival
MANAGEMENT
Humans
Survival rate
Retrospective Studies
business.industry
CENTRAL-NERVOUS-SYSTEM
3112 Neurosciences
3126 Surgery
anesthesiology
intensive care
radiology
medicine.disease
Clinical Study
EXPERIENCE
Histopathology
Neurology (clinical)
business
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Journal of Neuro-Oncology
ISSN: 1573-7373
0167-594X
Popis: PurposeSurgical series of pineal region gliomas are rarely available. Whereas it is a general assumption that the extent of surgical resection correlates with survival outcomes of intracranial gliomas; the impact of the microsurgical resection on the long-term outcomes of pineal gliomas has been questioned. We present a surgical series of pineal region gliomas with focus on the survival outcome analysis.Methods17 histologically confirmed pineal region glioma patients classified as diffuse and non-diffuse gliomas were retrospectively analyzed. A detailed description of the series was followed by regression models to identify predictors of clinical outcomes. Uni- a multivariate survival analysis was performed to determine independent predictors of mortality.ResultsAlthough the number of treated patients was small, only WHO grade histopathology remained significant (p = 0.02) after multivariate survival analysis with extent of resection, age, tumor volume, and preoperative functional status. The extent of the surgical resection did not correlate with the disease survival rates of non-diffuse (p = 1), diffuse (p = 0.2), nor all gliomas (p = 0.6). 15 of 17 patients underwent gross total (nine patients) or subtotal resection. The preoperative functional status of the patients showed overall improvement on the immediate (p ConclusionThe extent of the surgical resection does not seem to significantly impact on the survival outcomes of pineal region gliomas. Thus, genotype and molecular features may essentially affect the outcome. Further research on the field is required.
Databáze: OpenAIRE
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