Regulation of microRNA function in animals
| Autor: | Gebert Lfr, Ian J. MacRae |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cytoplasm
Cellular differentiation Computational biology Biology Article 03 medical and health sciences 0302 clinical medicine Neoplasms microRNA Animals Homeostasis Humans Molecular Biology Cellular localization 030304 developmental biology 0303 health sciences Cell Differentiation Cell Biology Argonaute Subcellular localization MicroRNAs Argonaute Proteins Research questions Protein Processing Post-Translational 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Nature Reviews Molecular Cell Biology. 20:21-37 |
| ISSN: | 1471-0080 1471-0072 |
| DOI: | 10.1038/s41580-018-0045-7 |
| Popis: | Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as key regulators of biological processes in animals. These small RNAs form complex networks that regulate cell differentiation, development and homeostasis. Deregulation of miRNA function is associated with an increasing number of human diseases, particularly cancer. Recent discoveries have expanded our understanding of the control of miRNA function. Here, we review the mechanisms that modulate miRNA activity, stability and cellular localization through alternative processing and maturation, sequence editing, post-translational modifications of Argonaute proteins, viral factors, transport from the cytoplasm and regulation of miRNA–target interactions. We conclude by discussing intriguing, unresolved research questions. MicroRNAs (miRNAs) are key regulators of biological processes. Recent discoveries have expanded our understanding of the control of miRNA function in animals, through alternative processing, miRNA-sequence editing, post-translational modifications of Argonaute proteins, subcellular localization and regulation of miRNA–target interactions. |
| Databáze: | OpenAIRE |
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