An Approach to 3,6-Disubstituted 2,5-Dioxybenzoquinones via Two Sequential Suzuki Couplings. Three-Step Synthesis of Leucomelone
| Autor: | Wei Jiang, Lihong Hu, Xianwen Gan, Wei Wang |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Molecular Structure
Chemistry Stereochemistry TNF-alpha production Organic Chemistry Catechols Total synthesis Leucomelone Thelephora vialis Boronic Acids Biochemistry Combinatorial chemistry Catalysis Suzuki reaction Yield (chemistry) Benzoquinones Combinatorial Chemistry Techniques Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 11:589-592 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol802645f |
| Popis: | Two sequential Suzuki coupling reactions have been developed for efficient synthesis of synthetically and biologically important 3,6-disubstituted 2,5-dioxybenzoquinone architectures in a highly chemoselective controlled manner. The method serves as a key step in the total synthesis of leucomelone in three steps and in 61% overall yield. |
| Databáze: | OpenAIRE |
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