Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer
| Autor: | Sheng Wang, Nan Ge, Dong-Yan Liu, Xinzhu Sun, Guoxin Wang, Jintao Guo, Siyu Sun, Xiang Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment pancreatic cancer Review Disease Metastasis Targeted therapy 03 medical and health sciences 0302 clinical medicine Circular RNA Pancreatic cancer microRNA Medicine biological function Competing endogenous RNA business.industry RNA circular RNA targeted therapy medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research biomarker business |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s308809 |
| Popis: | There are few biomarkers available for the early diagnosis and prognostic evaluation of pancreatic cancer. In addition, the development of targeted therapy for pancreatic cancer is an unmet need due to the lack of molecular targets. With the continuous progress in circular RNA (circRNA)-related research, its role in the occurrence and development of pancreatic cancer has been discovered and gradually recognized. Therefore, circRNA may represent a novel marker for early diagnosis of this disease and a focus of targeted clinical therapy. CircRNA is a type of non-coding RNA with a closed circular structure formed by covalent bonds. Some circRNAs can act as “sponges” to adsorb microRNAs (miRNAs) and play the role of competitive endogenous RNA (ceRNA) to remove their inhibitory effects on the target genes of miRNA. Thus, they can indirectly restore the expression of target genes. The circRNA–miRNA–mRNA network plays a regulatory role in the proliferation, invasion, metastasis, and other biological behaviors of pancreatic cancer. Given the recent advances in circRNA, this review seeks to provide an overview of the biological function of circRNA and highlights the recent research progress regarding the molecular mechanism of circRNA for the clinical diagnosis and treatment of pancreatic cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|