Esmolol Added in Repeated, Cold, Oxygenated Blood Cardioplegia Improves Myocardial Function After Cardiopulmonary Bypass
| Autor: | Finn Eliassen, Anne K. Jonassen, Pirjo-Riitta Salminen, Geir Olav Dahle, Knut Matre, Christian Arvei Moen, Ketil Grong, Rune Haaverstad |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Cardiac function curve medicine.medical_specialty Swine esmolol Doppler imaging law.invention Propanolamines Random Allocation law beta-blockade Internal medicine Cardiopulmonary bypass Animals Medicine Weaning Blood cardioplegia Cardioplegic Solutions business.industry Myocardial function Esmolol Adrenergic beta-1 Receptor Antagonists Cold Temperature Oxygen Preload Anesthesiology and Pain Medicine Anesthesia Heart Arrest Induced Cardiology Female cardioplegia cardiac function cardiopulmonary bypass Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia |
| ISSN: | 1053-0770 |
| DOI: | 10.1053/j.jvca.2014.09.017 |
| Popis: | Objective: This study investigated if the β-receptor blocking agent esmolol, added to standard oxygenated blood cardioplegia, improved myocardial function after weaning from bypass. Design: A block-randomized, blinded study. Setting: A university laboratory. Participants: Twenty anesthetized pigs, Norwegian Landrace. Interventions: After cardiopulmonary bypass, cardiac arrest was induced with cold (12°C), oxygenated blood cardioplegia, enriched with either esmolol or vehicle, repeated every 20 minutes. After 100 minutes the heart was reperfused and weaned. Measurements and Main Results: Left ventricular function was evaluated with pressure-volume loops, local myocardial function with multilayer strain and strain rate by epicardial short-axis tissue Doppler imaging. One hour after declamping, preload recruitable stroke work did not differ between groups, but increased to 72±3 mmHg in esmolol-treated animals v 57±4 mmHg (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect