Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease
| Autor: | Carlos Oliva, Julia Carracedo, Ignacio González de Pablos, Manuel Praga, Rafael J. Ramirez, Matilde Alique, Claudia Yuste, Andrea Figuer, Noemí Ceprián, Enrique Morales, Jara Caro, Gemma Valera, Nadia Serroukh |
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| Přispěvatelé: | Universidad de Alcalá. Departamento de Biología de Sistemas |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
Immunosenescence Medicina CD14 Lymphocyte Immune system R5-920 Chronic kidney disease Medicine Kidney transplantation Original Research immunosenescence business.industry Immunity Renal transplantation General Medicine renal transplantation medicine.disease immunity Microvesicles Transplantation medicine.anatomical_structure Immunology business microvesicles chronic kidney disease Kidney disease |
| Zdroj: | Frontiers in Medicine Frontiers in Medicine, Vol 8 (2021) e_Buah Biblioteca Digital Universidad de Alcalá instname |
| ISSN: | 2296-858X |
| Popis: | Kidney transplantation is the best option for patients with end-stage renal disease. Despite the improvement in cardiovascular burden (leading cause of mortality among patients with chronic kidney disease), cardiovascular adverse outcomes related to the inflammatory process remain a problem. Thus, the aim of the present study was to characterize the immune profile and microvesicles of patients who underwent transplantation. We investigated the lymphocyte phenotype (CD3, CD4, CD8, CD19, and CD56) and monocyte phenotype (CD14, CD16, CD86, and CD54) in peripheral blood, and endothelium-derived microvesicles (annexin V+CD31+CD41&-) in plasma of patients with advanced chronic kidney disease (n = 40), patients with transplantation (n = 40), and healthy subjects (n = 18) recruited from the University Hospital "12 de Octubre" (Madrid, Spain). Patients with kidney transplantation had B-cell lymphopenia, an impairment in co-stimulatory (CD86) and adhesion (CD54) molecules in monocytes, and a reduction in endothelium-derived microvesicles in plasma. The correlations between those parameters explained the modifications in the expression of co-stimulatory and adhesion molecules in monocytes caused by changes in lymphocyte populations, as well as the increase in the levels of endothelial-derived microvesicles in plasma caused by changes in lymphocyte and monocytes populations. Immunosuppressive treatment could directly or indirectly induce those changes. Nevertheless, the particular characteristics of these cells may partly explain the persistence of cardiovascular and renal alterations in patients who underwent transplantation, along with the decrease in arteriosclerotic events compared with advanced chronic kidney disease. In conclusion, the expression of adhesion molecules by monocytes and endothelial-derived microvesicles is related to lymphocyte alterations in patients with kidney transplantation. Instituto de Salud Carlos III Sociedad Española de Nefrología Comunidad de Madrid Fondo Social Europeo |
| Databáze: | OpenAIRE |
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