Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer
| Autor: | Ayla O'Keeffe, Alex L Wilkinson, Shishir Shetty, Daniel A. Patten |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Inflammation
Receptors Scavenger Innate immune system Hepatology media_common.quotation_subject Pattern recognition receptor Biology Atherosclerosis medicine.disease Hepatitis Cell biology Pathogenesis Liver disease Neoplasms medicine Humans Scavenger receptor medicine.symptom Receptor Internalization media_common |
| Zdroj: | Seminars in Liver Disease. 42:061-076 |
| ISSN: | 1098-8971 0272-8087 |
| Popis: | The scavenger receptor superfamily represents a highly diverse collection of evolutionarily-conserved receptors which are known to play key roles in host homeostasis, the most prominent of which is the clearance of unwanted endogenous macromolecules, such as oxidized low-density lipoproteins, from the systemic circulation. Members of this family have also been well characterized in their binding and internalization of a vast range of exogenous antigens and, consequently, are generally considered to be pattern recognition receptors, thus contributing to innate immunity. Several studies have implicated scavenger receptors in the pathophysiology of several inflammatory diseases, such as Alzheimer's and atherosclerosis. Hepatic resident cellular populations express a diverse complement of scavenger receptors in keeping with the liver's homeostatic functions, but there is gathering interest in the contribution of these receptors to hepatic inflammation and its complications. Here, we review the expression of scavenger receptors in the liver, their functionality in liver homeostasis, and their role in inflammatory liver disease and cancer. |
| Databáze: | OpenAIRE |
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