Hippocampal size in women but not men with schizophrenia relates to disorder duration
| Autor: | Eva Irle, Godehard Weniger, Mirjana Ruhleder, Cornelia Exner, Jakob Siemerkus, Claudia Lange |
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| Přispěvatelé: | University of Zurich, Irle, E |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Time Factors Cross-sectional study Neuroscience (miscellaneous) Physiology Hippocampus 610 Medicine & health Hippocampal formation 10056 Clinic for Clinical and Social Psychiatry Zurich West (former) 03 medical and health sciences 2738 Psychiatry and Mental Health Young Adult 0302 clinical medicine mental disorders medicine Image Processing Computer-Assisted 2741 Radiology Nuclear Medicine and Imaging Humans Radiology Nuclear Medicine and imaging Longitudinal Studies Young adult Psychiatry Psychiatric Status Rating Scales Analysis of Variance Sex Characteristics Reproducibility of Results Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies 2801 Neuroscience (miscellaneous) Schizophrenia Disease Progression Female Analysis of variance Psychology 030217 neurology & neurosurgery Sex characteristics |
| Zdroj: | Psychiatry research. 192(3) |
| ISSN: | 0165-1781 |
| Popis: | Longitudinal studies have failed to find progressive hippocampal size reduction in schizophrenia. However, negative results may have been due to follow-up intervals at disease stages where no significant progressive brain changes occur. Furthermore, only male or mixed gender samples have been studied. Forty-six patients with schizophrenia (23 females) and 46 healthy controls (23 females) underwent three-dimensional structural magnetic resonance imaging of the hippocampus and a clinical investigation. Compared with controls, male but not female participants with schizophrenia displayed hippocampal size reduction. Hippocampal size of female but not male schizophrenia patients was related to disorder duration, indicating smaller hippocampal size in female patients with longer disorder duration. Female schizophrenia patients displayed normal hippocampal size at the onset of disorder, but similarly reduced hippocampal size as male schizophrenia patients after some years of illness had passed. Our results suggest preserved hippocampal size in women with schizophrenia during the first years of illness. |
| Databáze: | OpenAIRE |
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