| Popis: |
A comparison was made of aqueous tubocurarine and a repository D-tubocurarine chloride suspension (Tubadi®) for muscle relaxant effectiveness and toxicity in rabbits. As compared with intravenous aqueous tubocurarine on the basis of lethal dose, intramuscular aqueous tubocurarine was one-half as toxic, intravenous Tubadil one-third as toxic, and intramuscular Tubadil only one-tenth as toxic. Deaths from aqueous tubocurarine occurred very soon after injection, whereas those from Tubadil were delayed, occurring after a prolonged period of gradually deepening respiratory depression. Duration of muscle relaxation was determined at sublethal dosages which produced the same average maximum severity of reaction, i. e., complete ataxia, and therefore had the same degree of safety. The muscle relaxation achieved with intramuscular Tubadil was 8 times as long as with intramuscular aqueous tubocurarine and 30 times as long as with intravenous aqueous tubocurarine. Over- curarization with Tubadil was counteracted by Tensilon® or neostigmine, the longer-acting neostigmine appearing more effective. |
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