Current concepts in osteolysis
| Autor: | Ian M. Clark, Simon T. Donell, Benjamin J Ollivere, J. A. Wimhurst |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Osteolysis business.industry Mechanism (biology) Arthroplasty Replacement Hip Wear debris Total hip replacement Osteoclasts Macrophage Activation Clinical literature medicine.disease Surgery medicine Humans Orthopedics and Sports Medicine business Neuroscience Signal Transduction |
| Zdroj: | The Journal of Bone and Joint Surgery. British volume. :10-15 |
| ISSN: | 2044-5377 0301-620X |
| DOI: | 10.1302/0301-620x.94b1.28047 |
| Popis: | The most frequent cause of failure after total hip replacement in all reported arthroplasty registries is peri-prosthetic osteolysis. Osteolysis is an active biological process initiated in response to wear debris. The eventual response to this process is the activation of macrophages and loss of bone.Activation of macrophages initiates a complex biological cascade resulting in the final common pathway of an increase in osteolytic activity. The biological initiators, mechanisms for and regulation of this process are beginning to be understood. This article explores current concepts in the causes of, and underlying biological mechanism resulting in peri-prosthetic osteolysis, reviewing the current basic science and clinical literature surrounding the topic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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