Lactate dehydrogenase isoenzymes in patients with acute exacerbation of chronic obstructive pulmonary disease: An exploratory cross-sectional study

Autor: Demosthenes Makris, Zoe Daniil, Charalampos Koufopoulos, Eleni Papaefstathiou, Vlasios Skopas, Konstantinos I. Gourgoulianis, Dimitrios Papadopoulos, Nikolaos Trakas
Rok vydání: 2021
Předmět:
Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Acute exacerbation of chronic obstructive pulmonary disease
Cross-sectional study
Physiology
Pilot Projects
Sensitivity and Specificity
Gastroenterology
Hypoxemia
Diagnosis
Differential
Pulmonary Disease
Chronic Obstructive
03 medical and health sciences
0302 clinical medicine
Internal medicine
Lower respiratory tract infection
medicine
Humans
Respiratory system
Respiratory Tract Infections
Aged
Aged
80 and over
COPD
L-Lactate Dehydrogenase
Respiratory tract infections
business.industry
General Neuroscience
Middle Aged
Symptom Flare Up
medicine.disease
Confidence interval
Isoenzymes
Cross-Sectional Studies
030228 respiratory system
Acute Disease
Arterial blood
Female
medicine.symptom
business
Biomarkers
030217 neurology & neurosurgery
Zdroj: Respiratory Physiology & Neurobiology. 283:103562
ISSN: 1569-9048
DOI: 10.1016/j.resp.2020.103562
Popis: We aimed to evaluate differences in serum lactate dehydrogenase (LDH) isoenzymes between patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and other lower respiratory tract infections (LRTIs). Based on self-reported COPD diagnosis, 71 participants were divided into AECOPD (n = 38, 29 males, mean age 70.5 years) and LRTI (n = 33, 12 males, mean age 70.4 years) groups. Information on demographics, comorbidities, and COPD severity markers, as well as arterial blood gases and laboratory data were collected, while serum LDH electrophoresis was performed to examine the LDH isoenzymes. Adjusting for sex, age, comorbidities, degree of hypoxemia, inflammation markers, muscle and myocardial enzymes, and total serum LDH, the mean differences (95 % confidence intervals) in the ratios of serum LDH isoenzymes to total serum LDH between groups (LDHxAECOPD - LDHxLRTI) were statistically significant for LDH1 [4.9 (1.4 to 8.3)], LDH2 [3.0 (0.1 to 5.8)], LDH3 [-4.3 (-6.3 to -2.3)], and LDH4 [-3.2 (-4.9 to -1.5)]. A sum of LDH3 and LDH4 ratios below 29 % had the highest discriminative ability to classify a subject in the AECOPD group (AUC 0.841, sensitivity 76 %, specificity 87 %). Aerobic metabolic adaptive mechanisms in respiratory muscles during AECOPD could explain the above differences.
Databáze: OpenAIRE
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