Primary Carcinoma of the Fallopian Tube: A Review of a Single Institution Experience of 8 Cases
| Autor: | Bafna D. Uttamchand, Praveen S. Rathod, Namrata N. Rajkumar, U. K. Devi, Pallavi V. Ramachandra, Shakuntala P. Nanaiah, Anbukkani Subbian, Abhilasha Narayan, Rajshekar Kundargi, Shobha Krishnappa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Article Subject medicine.medical_treatment Fallopian tube carcinoma lcsh:Medicine lcsh:Technology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Fallopian Tube Neoplasm Recurrence Carcinoma Medicine Fallopian Tube Neoplasms Humans Stage (cooking) lcsh:Science General Environmental Science Aged Chemotherapy business.industry lcsh:T lcsh:R Retrospective cohort study General Medicine Middle Aged medicine.disease Carboplatin Surgery medicine.anatomical_structure Treatment Outcome chemistry Female lcsh:Q business Fallopian tube Research Article |
| Zdroj: | The Scientific World Journal, Vol 2014 (2014) The Scientific World Journal |
| ISSN: | 2356-6140 |
| DOI: | 10.1155/2014/630731 |
| Popis: | Aims and Objectives. To evaluate the clinicopathologic features, response to cytoreductive surgery and adjuvant platinum-based chemotherapy with or without paclitaxel.Materials and Methods. A retrospective observational study of 8 women with a histopathologic diagnosis of primary fallopian tube carcinoma (PFTC) from January 2000 to February 2013.Results. 4/8 (50%) of the women were in the early stage and an intraoperative frozen section was 100% effective in identifying fallopian tube carcinoma and then a staging laparotomy was performed. All 4/8 cases in the early stage had received and responded to single agent carboplatin and all are alive without clinical, radiological, or biochemical evidence of recurrence at the end of 2 years and the longest survivor has completed 13 years. Primary optimal cytoreductive surgery was achievable in 3/4 (75%) in advanced disease. All showed response to adjuvant paclitaxel and carboplatin (T+C), but all had succumbed to the disease following recurrence with mean progression-free survival of 19 months (range 15–21 months) and mean overall survival of 27 months (range 22–36 months).Conclusion. The pivotal role played by a frozen section in diagnosing PFTC which is rare needs to be reemphasized, therefore justifying a primary staging laparotomy in an early stage. Prolonged survival observed in this group following an optimum tailored adjuvant single agent carboplatin is worth noting. |
| Databáze: | OpenAIRE |
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