A Miracle That Accelerates Operating Room Functionality: Sugammadex
| Autor: | Mahir Kuyumcu, Abdulmenap Güzel, Zeynep Baysal Yildirim, Mehmet Salim Akdemir, Erdal Doğan, Mehmet Besir Yildirim, Hakan Akelma, Abdurrahman Gümüş |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Operating Rooms medicine.medical_specialty Time Factors Article Subject lcsh:Medicine Blood Pressure Sugammadex General Biochemistry Genetics and Molecular Biology medicine Humans General anaesthesia In patient Acute respiratory failure Rocuronium Pulse State hospital Demography General Immunology and Microbiology business.industry lcsh:R General Medicine Middle Aged Neostigmine Surgery Anesthesia Clinical Study Female business Neuromuscular Blockers gamma-Cyclodextrins medicine.drug |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2014/945310 |
| Popis: | Background.Sugammadex offers a good alternative to the conventional decurarisation process currently performed with cholinesterase inhibitors. Sugammadex, which was developed specifically for the aminosteroid-structured rocuronium and vecuronium neuromuscular blockers, is a modified cyclodextrin made up of 8 glucose monomers arranged in a cylindrical shape.Methods.In this study, the goal was to investigate the efficacy of sugammadex. Sugammadex was used when there was insufficient decurarisation following neostigmine. This study was performed on 14 patients who experienced insufficient decurarisation (TOF<0.9) with neostigmine after general anaesthesia in the operating rooms of a university and a state hospital between June, 2012, and January, 2014. A dose of 2 mg/kg of sugammadex was administered.Results.Time elapsed until sugammadex administration following neostigmine37 ± 6min, following sugammadex it took2.1 ± 0.9min to reach TOF≥ 0.9, and the extubation time was3.2 ± 1.4min. No statistically significant differences were detected in the hemodynamic parameters before and after sugammadex application. From the time of administration of sugammadex to the second postoperative hour, no side effects or complications occurred. None of the patients experienced acute respiratory failure or residual block during this time period.Conclusion.Sugammadex was successfully used to reverse rocuronium-induced neuromuscular block in patients where neostigmine was insufficient. |
| Databáze: | OpenAIRE |
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