E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers
| Autor: | Ivona Bandilovska, Simon P. Keam, Cristina Gamell, Ygal Haupt, Claudia Machicado, Sue Haupt |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Carcinogenesis Ubiquitin-Protein Ligases viruses Hepacivirus Hepatitis C virus medicine.disease_cause Virus 03 medical and health sciences 0302 clinical medicine Neoplasms Angelman syndrome medicine Humans Encephalomyocarditis virus Papillomaviridae biology Papillomavirus Infections Cancer General Medicine biology.organism_classification medicine.disease Ubiquitin ligase 030104 developmental biology 030220 oncology & carcinogenesis Host-Pathogen Interactions biology.protein Cancer research |
| Zdroj: | Carcinogenesis. 40:707-714 |
| ISSN: | 1460-2180 0143-3334 |
| Popis: | Since its discovery, the E3 ubiquitin ligase E6-associated protein (E6AP) has been studied extensively in two pathological contexts: infection by the human papillomavirus (HPV), and the neurodevelopmental disorder, Angelman syndrome. Vital biological links between E6AP and other viruses, namely hepatitis C virus and encephalomyocarditis virus, have been recently uncovered. Critically, oncogenic E6AP activities have been demonstrated to contribute to cancers of both viral and non-viral origins. HPV-associated cancers serve as the primary example of E6AP involvement in cancers driven by viruses. Studies over the past few years have exposed a role for E6AP in non-viral-related cancers. This has been demonstrated in B-cell lymphoma and prostate cancers, where oncogenic E6AP functions drive these cancers by acting on key tumour suppressors. In this review we discuss the role of E6AP in viral infection, viral propagation and viral-related cancer. We discuss processes affected by oncogenic E6AP, which promote cancers of viral and non-viral aetiology. Overall, recent findings support the role of oncogenic E6AP in disrupting key cellular processes, including tumour suppression and the immune response. E6AP is consequently emerging as an attractive therapeutic target for a number of specific cancers. |
| Databáze: | OpenAIRE |
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