Regulation of aerobic glycolysis by long non-coding RNAs in cancer
| Autor: | Xiaojian Zhang, Xiangzhen Kong, Lihua Zuo, Jian Kang, Shou-Sen Hu, Zhenfeng Zhu, Xin Tian, Zhi Sun |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biophysics Cancer therapy Computational biology Biology Biochemistry 03 medical and health sciences Cell Line Tumor Neoplasms microRNA medicine Animals Humans Molecular Targeted Therapy Molecular Biology Cancer Cell Biology medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology Anaerobic glycolysis Cancer metabolism RNA Long Noncoding Glycolysis Signal Transduction |
| Zdroj: | Biochemical and biophysical research communications. 479(1) |
| ISSN: | 1090-2104 |
| Popis: | As with miRNAs a decade ago, long non-coding RNAs (lncRNAs) are emerging as a new class of RNAs involved in physiological and pathological processes. Recent evidences have shown that lncRNAs play a role in cancer metabolism. The relationship between lncRNAs and aerobic glycolysis provides new strategies for the treatment of cancer. Here we discuss recent findings on the role of lncRNAs in aerobic glycolysis and provide insights into their mechanisms of action. In addition, we explore the potential challenges in using lncRNAs as targets for cancer therapy. |
| Databáze: | OpenAIRE |
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