The effect of smoking and drinking in oral and pharyngeal cancers: A case-control study in Uruguay
| Autor: | Paolo Boffetta, Giselle Acosta, Fernando Oreggia, Eduardo De Stefani, Gilles Ferro, Alvaro L. Ronco, Hugo Deneo-Pellegrini, Juan Leiva |
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| Přispěvatelé: | De Stefani, E., Boffetta, P., Deneo-Pellegrini, H., Ronco, A.L., Acosta, G., Ferro, G., Oreggia, F., Leiva, J. |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty The effect of smoking and drinking in oral and pharyngeal cancers: a case-control study in Uruguay Alcohol Drinking Interviews as Topic Age Distribution Oral carcinomas Surveys and Questionnaires Internal medicine Pharyngeal cancer Odds Ratio medicine Humans Aged Aged 80 and over business.industry Smoking Case-control study Cancer Pharyngeal Neoplasms Odds ratio Middle Aged medicine.disease Surgery Social Class Oncology Case-Control Studies Uruguay Oral Cancers Mouth Neoplasms business |
| Popis: | In the time period 1988-2000, a case-control study on oral and pharyngeal cancers was conducted among men in Montevideo, Uruguay. The study included 776 cases and 1501 controls. The cases were distributed by site in oral cancers (335 patients) and pharyngeal cancers (441 patients). Odds ratios for smoking were higher among participants with pharyngeal cancers compared with those with oral carcinomas, but there was no significant heterogeneity. On the contrary, alcohol drinking displayed statistically higher risks among those with pharyngeal carcinomas compared with patients with oral cancer (P-value for heterogeneity=0.01). The effect of alcohol was particularly strong for cancers of the hypopharynx. Our results raise the possibility that oral and pharyngeal carcinomas are in fact different entities. Further studies are needed in order to clarify this important point. © 2006 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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