Intracoronary β-Irradiation With a Rhenium-188–Filled Balloon Catheter
| Autor: | Matthias Kochs, Jörg Kotzerke, Olaf Grebe, Sven N. Reske, Hartmut Hanke, Joachim Kamenz, Markus Wohlfrom, Jochen Wöhrle, Vinzenz Hombach, Thorsten Nusser, Martin Höher |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Target lesion medicine.medical_specialty medicine.medical_treatment Brachytherapy Coronary Artery Disease Coronary Angiography Revascularization Catheterization law.invention Coronary Restenosis Postoperative Complications Randomized controlled trial Restenosis law Physiology (medical) Angioplasty medicine Humans Angioplasty Balloon Coronary Vascular Patency Radioisotopes business.industry Balloon catheter Stent Dose-Response Relationship Radiation Middle Aged medicine.disease Beta Particles Surgery Rhenium Treatment Outcome Female Cardiology and Cardiovascular Medicine Complication business Nuclear medicine |
| Zdroj: | Circulation. 107:3022-3027 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.0000074203.66371.29 |
| Popis: | Background— Restenosis requiring reintervention is the main limitation of coronary angioplasty. Intracoronary irradiation reduces neointimal proliferation. We studied the efficacy of a self-centering liquid rhenium-188–filled balloon catheter for coronary β-brachytherapy. Methods and Results— After successful coronary angioplasty with or without stenting, 225 patients (71% de novo lesions) were randomly assigned to receive 22.5 Gy intravascular β-irradiation in 0.5-mm tissue depth (n=113) or to receive no additional intervention (n=112). Clinical and procedural data did not differ between the groups except a higher rate of stenting in the control group (63%) compared with the rhenium-188 group (45%, P P P P P P =0.006). Conclusions— Intracoronary β-brachytherapy with a rhenium-188 liquid-filled balloon is safe and efficiently reduces restenosis and revascularization rates after coronary angioplasty. |
| Databáze: | OpenAIRE |
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