| Autor: |
Matthew P, Smeltzer, Wei, Liao, Nicholas R, Faris, Carrie, Fehnel, Jordan, Goss, Catherine J, Shepherd, Rodolfo, Ramos, Talat, Qureshi, Ayesha, Mukhopadhyay, Meredith A, Ray, Raymond U, Osarogiagbon |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Thoracic Oncology. 18:158-168 |
| ISSN: |
1556-0864 |
| DOI: |
10.1016/j.jtho.2022.09.220 |
| Popis: |
Low Dose CT screening (LDCT) reduces lung cancer mortality, but current eligibility criteria underestimate risk in women and racial minorities. We evaluated the impact of screening criteria modifications on LDCT eligibility and lung cancer detection.Using data from a Lung Nodule Program, we compared persons eligible for LDCT by: US Preventive Services Task Force (USPSTF) 2013 criteria (55-80 years, ≥30 pack-years of smoking, and ≤15 years since cessation (USPSTF2013); USPSTF 2021 (50-80 years, ≥20 pack-years of smoking, and ≤15 years since cessation (USPSTF2021); quit duration expanded to ≤25 years (USPSTF2021-QD25); reducing the pack-years of smoking to ≥10 (USPSTF2021-PY10); and both (USPSTF2021-QD25-PY10). We compare across groups using the chi-square test or Analysis of Variance.The 17,421 individuals analyzed were 56% female, 69% White, 28% Black; 13% met USPSTF2013 criteria; 17% USPSTF2021; 18% USPSTF2021-QD25; 19% USPSTF2021-PY10; and 21% USPSTF2021-QD25-PY10. Additional eligible individuals by USPSTF2021 (n=682) and USPSTF2021-QD25-PY10 (n=1402) were 27% and 29% Black, both significantly higher than USPSTF2013 (17%, p-values0.0001). These additional eligible individuals were 55% (USPSTF2021) and 55% (USPSTF2021-QD25-PY10) female, compared to 48% by USPSTF2013 (p-values0.05). Of 1,243 (7.1%) persons with lung cancer, 22% were screening-eligible by USPSTF13. USPSTF2021-QD25-PY10 increased the total number of persons with lung cancer by 37%. These additional individuals with lung cancer were 57% female (vs 48% with USPSTF2013, p-value= 0.0476) and 24% black (vs 20% with USPSTF2013, p-value= 0.3367).Expansion of LDCT screening eligibility criteria to allow longer quit-duration and fewer pack-years of exposure enriches the screening-eligible population for women and Black persons. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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