Intestinal barrier function in morbid obesity: results of a prospective study on the effect of sleeve gastrectomy
| Autor: | Simon W. Nienhuijs, Zlatan Mujagic, Freddy J. Troost, Hans M.H. van Eijk, Kirsten E. Pijls, Ad A.M. Masclee, Tim Klaassen, Mark van Avesaat, Arnold Stronkhorst, Ellen Wilms, Nienke Bernards, Jennifer Wilbrink |
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| Přispěvatelé: | MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), RS: NUTRIM - R2 - Liver and digestive health, Interne Geneeskunde, Surgery, MUMC+: MA Maag Darm Lever (9) |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Sleeve gastrectomy Endocrinology Diabetes and Metabolism medicine.medical_treatment Urinary system GASTRIC BYPASS WEIGHT-LOSS Medicine (miscellaneous) 030209 endocrinology & metabolism Overweight Gastroenterology DISEASE 03 medical and health sciences FECAL CALPROTECTIN 0302 clinical medicine INFLAMMATION Weight loss Internal medicine ABSORPTION medicine 030212 general & internal medicine Prospective cohort study Barrier function BARIATRIC SURGERY OVERWEIGHT Nutrition and Dietetics business.industry GUT PERMEABILITY MICROBIOTA Gastrectomy medicine.symptom Calprotectin business |
| Zdroj: | International Journal of Obesity, 44(2), 368-376. Nature Publishing Group |
| ISSN: | 1476-5497 0307-0565 |
| Popis: | Background Obesity has been associated with impaired intestinal barrier function. It is not known whether bariatric surgery leads to changes in intestinal barrier function. We hypothesized that obesity is associated with disturbances in gastrointestinal barrier function, and that after bariatric surgery barrier function will improve. Methods Prospective single center study in which we assessed segmental gut permeability by urinary recovery of a multisugar drink in 27 morbidly obese (BMI 43.3 +/- 1.1 kg/m(2)) and 27 age and gender matched lean subjects (BMI 22.9 +/- 0.43 kg/m(2)). Fecal calprotectin, SCFAs, plasma cytokines, and hsCRP were assessed as inflammatory and metabolic markers. Comparisons: (a) morbidly obese subjects vs. controls and (b) 2 and 6 months postsleeve vs. presleeve gastrectomy (n = 14). In another group of 10 morbidly obese and 11 matched lean subjects colonic and ileal biopsies were obtained in order to measure gene transcription of tight junction proteins. Results Gastroduodenal permeability (urinary sucrose recovery) was significantly increased in obese vs. lean controls (p |
| Databáze: | OpenAIRE |
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