Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

Autor:	Christophe M. Capelle, Séverine Ciré, Olivia Domingues, Isabelle Ernens, Fanny Hedin, Aurélie Fischer, Chantal J. Snoeck, Wim Ammerlaan, Maria Konstantinou, Kamil Grzyb, Alexander Skupin, Cara L. Carty, Christiane Hilger, Georges Gilson, Aljosa Celebic, Paul Wilmes, Antonio Del Sol, Ian M. Kaplan, Fay Betsou, Tamir Abdelrahman, Antonio Cosma, Michel Vaillant, Guy Fagherazzi, Markus Ollert, Feng Q. Hefeng
Rok vydání:	2022
Předmět:	SARS-CoV-2 non-hospitalized COVID-19 combinatorial analysis systems immunology CD8-Positive T-Lymphocytes Antibodies Viral Antiviral Agents early-stage response General Biochemistry Genetics and Molecular Biology immunology transient cytokine response predict antibody levels Humans mild patients
Zdroj:	Capelle, C M, Ciré, S, Domingues, O, Ernens, I, Hedin, F, Fischer, A, Snoeck, C J, Ammerlaan, W, Konstantinou, M, Grzyb, K, Skupin, A, Carty, C L, Hilger, C, Gilson, G, Celebic, A, Wilmes, P, Del Sol, A, Kaplan, I M, Betsou, F, Abdelrahman, T, Cosma, A, Vaillant, M, Fagherazzi, G, Ollert, M & Hefeng, F Q 2022, ' Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients ', Cell Reports Medicine, vol. 3, no. 4, 100600 . https://doi.org/10.1016/j.xcrm.2022.100600
ISSN:	2666-3791
Popis:	While immunopathology has been widely studied in patients with severe COVID-19, immune responses in non-hospitalized patients have remained largely elusive. We systematically analyze 484 peripheral cellular or soluble immune features in a longitudinal cohort of 63 mild and 15 hospitalized patients versus 14 asymptomatic and 26 household controls. We observe a transient increase of IP10/CXCL10 and interferon-β levels, coordinated responses of dominant SARS-CoV-2-specific CD4 and fewer CD8 T cells, and various antigen-presenting and antibody-secreting cells in mild patients within 3 days of PCR diagnosis. The frequency of key innate immune cells and their functional marker expression are impaired in hospitalized patients at day 1 of inclusion. T cell and dendritic cell responses at day 1 are highly predictive for SARS-CoV-2-specific antibody responses after 3 weeks in mild but not hospitalized patients. Our systematic analysis reveals a combinatorial picture and trajectory of various arms of the highly coordinated early-stage immune responses in mild COVID-19 patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18e7bf892ea4f97477ba8eb53ae07af https://doi.org/10.1016/j.xcrm.2022.100600 Zobrazit plný text záznamu