C-Reactive Protein Causes Adult-Onset Obesity Through Chronic Inflammatory Mechanism
| Autor: | Mohamed A. Bayorh, Qing Song, Xiaodong Zhang, Qingwei Wang, Yamin Ma, Jin Zou, Wei Xu, James Champion, Shaojin You, Li Ma, Qi Wang, Lanbo Zhao, Ye Cui, Qing Wang, Wenzhi Li, Danita Eatman, Guangdi Wang, Yangyang Deng, Biao Wu, Qiling Li |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
obesity medicine.medical_specialty Inflammation Gut flora Cell and Developmental Biology 03 medical and health sciences 0302 clinical medicine Internal medicine Adult-onset obesity medicine lcsh:QH301-705.5 Original Research 2. Zero hunger Innate immune system medicine.diagnostic_test biology Mechanism (biology) business.industry C-reactive protein adult-onset Magnetic resonance imaging Cell Biology medicine.disease biology.organism_classification Obesity 030104 developmental biology Endocrinology lcsh:Biology (General) inflammation 030220 oncology & carcinogenesis gut flora biology.protein medicine.symptom CRP business Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology, Vol 8 (2020) Frontiers in Cell and Developmental Biology |
| ISSN: | 2296-634X |
| Popis: | Obesity is characterized by low-grade chronic inflammation. As an acute-phase reactant to inflammation and infection, C-reactive protein (CRP) has been found to be the strongest factor associated with obesity. Here we show that chronic elevation of human CRP at baseline level causes the obesity. The obesity phenotype is confirmed by whole-body magnetic resonance imaging (MRI), in which the total fat mass is 6- to 9- fold higher in the CRP rats than the control rats. Univariate linear regression analysis showed different growth rates between the CRP rats and the control rats, and that the difference appears around 11 weeks old, indicating that they developed adult-onset obesity. We also found that chronic elevation of CRP can prime molecular changes broadly in the innate immune system, energy expenditure systems, thyroid hormones, apolipoproteins, and gut flora. Our data established a causal role of CRP elevation in the development of adult-onset obesity. |
| Databáze: | OpenAIRE |
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