Human leukocyte antigen-G (HLA-G) expression in biliary epithelial cells is associated with allograft acceptance in liver-kidney transplantation
| Autor: | Catherine Menier, Antoine Durrbach, Nathalie Rouas-Freiss, Didier Samuel, Edgardo D. Carosella, Jean Dausset, Caroline Créput, Bernard Charpentier, Catherine Guettier |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Graft Rejection Male Pathology medicine.medical_specialty Biopsy Urinary system Human leukocyte antigen Kidney HLA Antigens HLA-G MHC class I Immune Tolerance medicine Humans Transplantation Homologous Biliary Tract HLA-G Antigens Hepatology biology business.industry Graft Survival Histocompatibility Antigens Class I Epithelial Cells Middle Aged Immunohistochemistry Kidney Transplantation Epithelium Liver Transplantation Transplantation surgical procedures operative medicine.anatomical_structure Liver Biliary tract Immunology biology.protein Female business |
| Zdroj: | Journal of Hepatology. 39:587-594 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/s0168-8278(03)00354-4 |
| Popis: | Background/Aims : Liver allograft is known to protect simultaneously transplanted organs from acute rejection. We have reported that only 6% of combined liver-kidney recipients, versus 32.5% of kidney recipients, develop kidney graft acute rejection. Release of soluble human leukocyte antigen (HLA) molecules by the liver has been proposed as a possible tolerogenic mechanism involved in the better acceptance of double transplants. The HLA-G molecule is acknowledged to possess tolerogenic properties. Methods : We investigated the involvement of HLA-G in allogeneic transplant acceptance by analyzing its expression in kidney and liver biopsies of 40 combined transplanted patients. Results : We demonstrate the presence of HLA-G in 14 out of 40 liver and five out of nine kidney transplants biopsies. HLA-G is expressed de novo by cells that are otherwise frequently susceptible target cells of acute rejection, i.e. liver biliary and renal tubular epithelial cells. We show a significant association between HLA-G expression in liver biliary epithelial cells and the absence of liver graft rejection. No acute or chronic rejection of the kidney graft was observed in patients in whom HLA-G was expressed in the liver graft. Conclusions : HLA-G expression in the liver allograft is associated with a lower frequency of hepatic and renal acute rejection and may be involved in the acceptance of simultaneously transplanted organs. |
| Databáze: | OpenAIRE |
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