Nipple Discharge of CA15-3, CA125, CEA and TSGF as a New Biomarker Panel for Breast Cancer

Autor: Meihua Qin, Junxi Zhang, Jinhui Zhao, Yun-Ai Liang, Zuofeng Zhang, Yanqing Sun, Gangping Wang, Yan Qin
Jazyk: angličtina
Rok vydání: 2014
Předmět:
CA15-3
Oncology
serological biomarker
Estrogen receptor
lcsh:Chemistry
Carcinoembryonic antigen
Epidermal growth factor receptor
lcsh:QH301-705.5
Spectroscopy
biology
cancer antigen 15-3
Nipple Aspirate Fluid
breast cancer
nipple discharge
cancer antigen 125
carcinoembryonic antigen
malignant tumor-specific growth factor
General Medicine
Middle Aged
Prognosis
Computer Science Applications
Neoplasm Proteins
Nipples
Female
medicine.symptom
Adult
Prognostic variable
medicine.medical_specialty
Breast Neoplasms
Catalysis
Article
Nipple discharge
Inorganic Chemistry
Young Adult
Breast cancer
Antigens
Neoplasm
Internal medicine
medicine
Biomarkers
Tumor
Humans
Physical and Theoretical Chemistry
Molecular Biology
Aged
business.industry
Organic Chemistry
Mucin-1
medicine.disease
lcsh:Biology (General)
lcsh:QD1-999
CA-125 Antigen
biology.protein
Cancer biomarkers
business
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 15; Issue 6; Pages: 9546-9565
International Journal of Molecular Sciences, Vol 15, Iss 6, Pp 9546-9565 (2014)
ISSN: 1422-0067
Popis: Breast cancer is the second leading cause of cancer death in women. Serum biomarkers such as cancer antigen 15-3 (CA15-3), cancer antigen 125 (CA125), and carcinoembryonic antigen (CEA) can be used as diagnostic and prognostic factors and can also provide valuable information during follow-up. However, serum protein biomarkers show limited diagnostic sensitivity and specificity in stand-alone assays because their levels reflect tumor burden. To validate whether biomarkers in nipple discharge may serve as novel biomarkers for breast cancer, we composed a panel of potential cancer biomarkers, including CA15-3, CA125, CEA, and malignant tumor-specific growth factor (TSGF), and evaluated their expression in both serum and nipple discharge in order to explore the expression and significance of estrogen receptor (ER), progestrone receptor (PR), epidermal growth factor receptor type 2 (HER2/neu), CA15-3, CA125, CEA, and TSGF expression for their combined predictive value for breast cancer and in judging the prognosis of breast cancer. Univariate analysis revealed that combined detection of CA15-3, CA125, CEA, and TSGF in nipple discharge served as novel biomarkers for the diagnosis and prognosis of breast cancer, but in the multivariate analyses the adverse effects of the four biomarkers combination in nipple discharge positivity on overall survival were lost. Multivariate analysis revealed that the positivity of the combined detection of the four biomarkers in both nipple discharge and serum was significantly higher than that of other detection methods. Thus, the combined detection of these four biomarkers both in serum and nipple discharge was retained as an independent prognostic variable in breast cancer patients. Our results indicate that CA15-3, CA125, CEA, and TSGF in nipple discharge can serve as novel biomarkers in the diagnosis and prognosis of breast cancer.
Databáze: OpenAIRE
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