A high-carbohydrate diet enhances the adverse effect of the S2 allele of APOC3 SstI polymorphism on the TG/HDL-C ratio only in young Chinese females
| Autor: | Ding Zhi Fang, Yuan Hao Li, Yong Yan Song, Zhen Zhang, Xue Dong Zhou, Li Ying Xiao, Ren Rong Gong |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Genotyping Techniques Apolipoprotein B Human APOC3 Physiology Blood lipids Biochemistry chemistry.chemical_compound Lipid ratio Genotype General Pharmacology Toxicology and Pharmaceutics lcsh:QH301-705.5 lcsh:R5-920 biology General Neuroscience Gene polymorphism General Medicine Cholesterol Apolipoprotein B-100 Female lipids (amino acids peptides and proteins) lcsh:Medicine (General) Heterozygote medicine.medical_specialty Immunology Biophysics Ocean Engineering Young Adult Sex Factors Asian People Internal medicine Dietary Carbohydrates medicine Humans Allele Adverse effect Alleles Triglycerides Apolipoprotein C-III Polymorphism Genetic Apolipoprotein A-I Triglyceride Cholesterol HDL High-carbohydrate diet Cholesterol LDL Cell Biology Carbohydrate Endocrinology lcsh:Biology (General) chemistry biology.protein |
| Zdroj: | Brazilian Journal of Medical and Biological Research v.44 n.6 2011 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 44, Iss 6, Pp 524-530 (2011) Brazilian Journal of Medical and Biological Research, Volume: 44, Issue: 6, Pages: 524-530, Published: JUN 2011 |
| ISSN: | 0100-879X |
| DOI: | 10.1590/s0100-879x2011007500065 |
| Popis: | Both genetic background and diet have profound effects on plasma lipid profiles. We hypothesized that a high-carbohydrate (high-CHO) diet may affect the ratios of serum lipids and apolipoproteins (apo) differently in subjects with different genotypes of the SstI polymorphism in the apoCIII gene (APOC3). Fifty-six healthy university students (27 males and 29 females, 22.89 ± 1.80 years) were given a washout diet of 54% carbohydrate for 7 days, followed by a high-CHO diet of 70% carbohydrate for 6 days without total energy restriction. Serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apoB100, apoAI, and the APOC3 SstI polymorphism were analyzed. The ratios of serum lipids and apoB100/apoAI were calculated. At baseline, the TG/HDL-C ratio was significantly higher in females, but not in males, with the S2 allele. The differences in the TG/HDL-C ratio between genotypes remained the same after the washout and the high-CHO diet in females. When compared with those before the high-CHO diet, the TC/HDL-C (male S2 carriers: 3.13 ± 1.00 vs 2.36 ± 0.65, P = 0.000; male subjects with the S1S1 genotype: 2.97 ± 0.74 vs 2.09 ± 0.55, P = 0.000; female S2 carriers: 2.68 ± 0.36 vs 2.24 ± 0.37, P = 0.004; female subjects with the S1S1 genotype: 2.69 ± 0.41 vs 2.09 ± 0.31, P = 0.000) and LDL-C/HDL-C (male S2 carriers: 1.44 ± 0.71 vs 1.06 ± 0.26, P = 0.012; male subjects with the S1S1 genotype: 1.35 ± 0.61 vs 1.01 ± 0.29, P = 0.005; female S2 carriers: 1.18 ± 0.33 vs 1.00 ± 0.18, P = 0.049; female subjects with the S1S1 genotype: 1.18 ± 0.35 vs 1.04 ± 0.19, P = 0.026) ratios were significantly decreased after the high-CHO diet regardless of gender and of genotype of the APOC3 SstI polymorphism. However, in female S2 carriers, the TG/HDL-C (1.38 ± 0.46 vs 1.63 ± 0.70, P = 0.039) ratio was significantly increased after the high-CHO diet. In conclusion, the high-CHO diet has favorable effects on the TC/HDL-C and LDL-C/HDL-C ratios regardless of gender and of genotype of the APOC3 SstI polymorphism. Somehow, it enhanced the adverse effect of the S2 allele on the TG/HDL-C ratio only in females. |
| Databáze: | OpenAIRE |
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