Heritability, parental transmission and environment correlation of pediatric-onset type 2 diabetes mellitus and metabolic syndrome-related traits
| Autor: | Miguel Klünder-Klünder, Samuel Flores-Huerta, Jenny Vilchis-Gil, Mario Molina-Díaz, América L Miranda-Lora |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Parents 0301 basic medicine Proband Adolescent Endocrinology Diabetes and Metabolism Parenteral transmission 030209 endocrinology & metabolism Pedigree chart Environment Biology 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Diabetes mellitus Mexican Americans Internal Medicine medicine Humans Insulin Family history Child Life Style Metabolic Syndrome Genetics Anthropometry Type 2 Diabetes Mellitus General Medicine Heritability medicine.disease Lipids Pedigree Cross-Sectional Studies Phenotype 030104 developmental biology Diabetes Mellitus Type 2 Female Insulin Resistance Metabolic syndrome Demography |
| Zdroj: | Diabetes Research and Clinical Practice. 126:151-159 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2017.02.005 |
| Popis: | To estimate the heritability, parental transmission and environmental contributions to the phenotypic variation in type 2 diabetes mellitus and metabolic syndrome-related traits in families of Mexican children and adolescents.We performed a cross-sectional study of 184 tri-generational pedigrees with a total of 1160 individuals (99 families with a type 2 diabetes mellitus proband before age 19). The family history of type 2 diabetes mellitus in three generations was obtained by interview. Demographic, anthropometric, biochemical and lifestyle information was corroborated in parents and offspring. We obtained correlations for metabolic traits between relative pairs, and variance component methods were used to determine the heritability and environmental components.The heritability of early-onset of type 2 diabetes mellitus was 0.50 (p1.0e-7). The heritability was greater than 0.5 for hypertension, hypoalphalipoproteinemia, hypercholesterolemia, body mass index, waist circumference, blood pressure, 2-h insulin, and cholesterol (p0.001). In contrast, we observed a high environmental correlation (0.50) for blood pressure, HbA1c and HDL-cholesterol after multivariate adjustment (p0.05). Several traits, such as type 2 diabetes mellitus and insulin resistance, were significantly correlated only through the mother and others, such as hypertriglyceridemia, were significantly correlated only through the father.This study demonstrates that type 2 diabetes mellitus and metabolic syndrome-related traits are highly heritable among Mexican children and adolescents. Furthermore, several cardiometabolic factors have strong heritability and/or high environmental contributions that highlight the complex architecture of these alterations. |
| Databáze: | OpenAIRE |
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