Severity of anxiety and depression are related to a higher perception of adverse effects of antiepileptic drugs
| Autor: | Bety Gómez-Arias, Rosario López-Zapata, Iris E. Martínez-Juárez, Daniel Crail-Melendez |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Neurology Antiepileptic drugs Clinical Neurology Anxiety Hospital Anxiety and Depression Scale Epilepsy Quality of life Epidemiology medicine Humans LAEP Adverse effect Psychiatry Mexico Depression (differential diagnoses) HADS Adverse effects Depression business.industry Mexican General Medicine medicine.disease Scale Anticonvulsants Female Neurology (clinical) medicine.symptom business |
| Zdroj: | Seizure. 21:588-594 |
| ISSN: | 1059-1311 |
| DOI: | 10.1016/j.seizure.2012.06.003 |
| Popis: | After reviewing the negative effects of antiepileptic drugs (AEDs) on general health and quality of life, the Commission on Outcome Measurement from the International League Against Epilepsy (ILAE) recommended incorporating reliable and valid tools in clinical essays in order to achieve a more accurate assessment of the subjective adverse effects rate and disease severity when using AEDs. Purpose The aim of this study was to correlate the severity of adverse effects of AEDs, with the presence of anxiety and depression in patients with epilepsy. Methods The Spanish version of the Liverpool Adverse Events Profile (LAEP) and the Hospital Anxiety and Depression Scale (HADS) were applied on 130 consecutive outpatients with epilepsy from the epilepsy clinic at the Mexico's National Institute of Neurology and Neurosurgery. A correlation analysis was carried out to determine if the presence of depression and anxiety was related to the adverse effects of AEDs. The relation between LAEP scores with other epidemiological variables was also assessed. Results Our study found a positive correlation between the LAEP and the HADS scores ( p = The most common adverse effects were drowsiness (81.5% [ n =106]), difficulty in concentrating (76% [ n =99]), and nervousness and/or agitation (75% [ n =97]). Female gender, a history of febrile seizures, persistent seizures and polytherapy were associated with a higher toxicity on LAEP. In our study, age at epilepsy onset, duration of epilepsy, type of epilepsy and patients' age were not related to higher LAEP scores. Conclusion Adverse effects to AEDs can be related with the presence of psychiatric disorders such as anxiety and depression in patients with epilepsy. |
| Databáze: | OpenAIRE |
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