High serum Ephrin‑B2 levels predict poor prognosis for patients with gastric cancer
| Autor: | Ming Li, Shao‑Jia Mou, Wen‑Jing Yue, Yi‑Pin Liu, Cheng‑Xia Liu, Zi‑Ping Chen, Qian‑Kun Li |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Small interfering RNA animal structures Cell Metastasis 03 medical and health sciences 0302 clinical medicine oncogene Medicine ephrin-B2 Survival analysis Oncogene business.industry gastric cancer therapeutic target Cancer Articles Cell cycle medicine.disease Molecular medicine 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis embryonic structures Cancer research prognosis sense organs business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | Gastric cancer is an intractable disease with a poor prognosis and limited treatment options. Its treatment remains a major clinical challenge worldwide. Ephrin-B2 is upregulated and involved in tumor growth in various types of cancer. However, the association between ephrin-B2 and prognosis of gastric cancer, and the potential of ephrin-B2 as a therapeutic target remains unknown. The present study investigated ephrin-B2 as a prognostic factor and a therapeutic target for gastric cancer. Reverse transcription-quantitative polymerase chain reaction was performed to detect the protein expression level of ephrin-B2 in gastric cancer serum samples (n=162) and healthy serum samples (n=165). It was revealed that the protein expression level of ephrin-B2 was significantly upregulated in gastric cancer serum samples compared with the healthy samples. Ephrin-B2 protein expression was associated with tumor size (P |
| Databáze: | OpenAIRE |
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