Experimental infection of the human granulocytic ehrlichiosis agent in horses
| Autor: | Donald H. Lein, Sang Shin, Susan J. Wong, Edward J. Dubovi, Frederick K. Chu, Vesna Novosel, Chao-Fu Chang, Fabio del Piero, Yung-Fu Chang |
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| Rok vydání: | 1998 |
| Předmět: |
DNA
Bacterial Male Pathology medicine.medical_specialty Ehrlichia Polymerase Chain Reaction Lymphatic System Human granulocytic Ehrlichia Peritoneum Adrenal Glands medicine Animals Humans Horses Fascia Muscle Skeletal music Lung Aged music.instrument General Veterinary Human blood biology Adrenal gland Ehrlichiosis Horse General Medicine Middle Aged Follicular hyperplasia Specific Pathogen-Free Organisms medicine.anatomical_structure Liver Immunology Ehrlichiosis (canine) biology.protein Horse Diseases Joints Parasitology Lymph Nodes Antibody Spleen |
| Zdroj: | Veterinary Parasitology. 78:137-145 |
| ISSN: | 0304-4017 |
| DOI: | 10.1016/s0304-4017(98)00133-2 |
| Popis: | Human blood collected from two patients from Westchester County, New York with human granulocytic ehrlichia (HGE) infection was inoculated into two ponies. Inoculated ponies developed clinical signs similar to a previous report (Madigan et al., 1995). Histopathological changes involved follicular hyperplasia of lymphoid tissues. HGE DNA was detected by PCR in muscle, fascia, peritoneum, and adrenal gland after the ponies produced a high level of antibodies to HGE. We suggest that HGE may reside in poorly vascularized connective tissues, where the antibodies may have some difficulties to penetrate, resulting in persistent infection. Since HGE and E. equi cause very similar diseases in both humans and horses, they may be the same organism with minor genetic differences. |
| Databáze: | OpenAIRE |
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