Low activity sn-glycerol-3-phosphate dehydrogenase variants in natural populations of Drosophila melanogaster
| Autor: | Darryl Reed, John B. Gibson, Jane E. Symonds, Anh Cao |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Glycerolphosphate Dehydrogenase
Dehydrogenase Gene Frequency Polymorphism (computer science) Drosophilidae Genetics Animals Alleles Genetics (clinical) chemistry.chemical_classification Chi-Square Distribution biology Australia Genetic variants Low activity Genetic Variation Electrophoresis Cellulose Acetate biology.organism_classification Europe Drosophila melanogaster Enzyme Glycerol-3-phosphate dehydrogenase chemistry Biochemistry North America |
| Zdroj: | Heredity. 66:75-82 |
| ISSN: | 1365-2540 0018-067X |
| DOI: | 10.1038/hdy.1991.10 |
| Popis: | Eleven Australian natural populations of Drosophila melanogaster were screened by electrophoresis for evidence of null and/or low activity variants at the Gdph locus. Of 5018 alleles investigated, 57 had markedly lower GDPH activity, as judged by their heterozygous phenotypes, than control alleles. GPDH assays of 13 of these variant alleles showed that whilst they were heterogeneous in their properties and included electrophoretic variants and two categories of low-activity variant, there were no true null alleles. The most common low-activity variants exhibited dominance for GPDH activity in heterozygotes with normal alleles, and were shown to share this property with an allele previously isolated from a London (UK) population (Langley et al., 1981). |
| Databáze: | OpenAIRE |
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