Once-weekly vancomycin for patients receiving high-flux hemodialysis
| Autor: | John J. Doran, Ted Walton, Brooke S Crawford, Rebecca F. Largen |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Georgia medicine.drug_class medicine.medical_treatment Antibiotics Once weekly Renal Dialysis Vancomycin Ambulatory Care medicine Humans Infusion pump Renal Insufficiency Dosing Dialysis Pharmacology business.industry Health Policy Middle Aged Anti-Bacterial Agents Surgery High flux Treatment Outcome Anesthesia Female Hemodialysis business medicine.drug |
| Zdroj: | American Journal of Health-System Pharmacy. 65:1248-1253 |
| ISSN: | 1535-2900 1079-2082 |
| DOI: | 10.2146/ajhp070466 |
| Popis: | Purpose. The effectiveness of a once-weekly vancomycin dosing protocol for patients receiving long-term high-flux hemodialysis (HFHD) in the outpatient setting was studied. Methods. Eligible patients were at least 18 years old, required hemodialysis for at least two months before study enrollment, and were not known to have any active infection. All patients received outpatient dialysis at a 1000-bed urban teaching hospital three times per week through a high-flux synthetic dialyzer. All patients received vancomycin 35 mg/kg, rounded to the nearest 250 mg, administered during hemodialysis at a rate of 1 g/hr via an infusion pump and scheduled to end when the hemodialysis session was over. Vancomycin was infused either predialyzer or postdialyzer, and infusion pumps were used in patients who received vancomycin through the postdialyzer access port. Serum vancomycin levels were measured before the third hemodialysis session (study day 8) to evaluate the percentage of patients who maintained therapeutic vancomycin concentrations of ≥10 μg/mL. Results. No patients achieved a vancomycin concentration of ≥10 μg/mL on study day 8 (mean serum concentration, 5.1 μg/mL). When patients were separated into two groups based on administration technique, six patients (83%) who received vancomycin predialyzer had undetectable vancomycin levels ( |
| Databáze: | OpenAIRE |
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