MRI Measurement of Upper Cervical Spinal Cord Cross-Sectional Area in Children
| Autor: | Roland G. Henry, Carlo Asteggiano, Michael Lauricella, Eduardo Caverzasi, Matthew Neylan, Gina Kirkish, Nico Papinutto, Christian Cordano, Maria Luisa Gorno-Tempini, Maria Luisa Mandelli, Nicole A Yabut |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Population Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Atrophy medicine Humans Radiology Nuclear Medicine and imaging Spinal canal education Child education.field_of_study Sex Characteristics medicine.diagnostic_test business.industry Cervical Cord Magnetic resonance imaging Spinal cord medicine.disease Magnetic Resonance Imaging Sagittal plane Skull medicine.anatomical_structure Upper cervical spinal cord Female Neurology (clinical) Radiology business 030217 neurology & neurosurgery Neck |
| Zdroj: | J Neuroimaging |
| ISSN: | 1552-6569 |
| Popis: | BACKGROUND AND PURPOSE Neurological and neurodegenerative diseases can affect the spinal cord (SC) of pediatric patients. Magnetic resonance imaging (MRI) allows for in vivo quantification of SC atrophy via cross-sectional area (CSA). The study of CSA values in the general population is important to disentangle disease-related changes from intersubject variability. This study aimed at providing normative values for cervical CSA in children, extending our previous work performed with adults. METHODS Seventy-eight children (age 7-17 years) were selected from a Developmental Dyslexia study. All subjects underwent a 3T brain MRI session and any incidental findings were reported on the scans. A sagittal 1 mm3 3-dimensional T1 -weighted brain acquisition extended to the upper cervical cord was used to measure CSA at C2-C3, as well as spinal canal area and skull volume (V-scale). These three metrics were linearly fitted as a function of age to extract trends and percentage annual changes. Sex differences of CSA were assessed using least squares regression analyses, adjusting for age. We tested normalization strategies proven to be effective in reducing the intersubject variability of adults' CSA. RESULTS CSA changed as a function of age at a faster rate when compared with skull volume (CSA: 1.82% increase, V-scale: .60% reduction). Sex had a statistically significant effect on CSA. Normalization methods based on canal area and skull volume reduced the CSA intersubject variability up to 16.84%. CONCLUSIONS We present CSA normative values in a large cohort of children, reporting on sources of intersubject variability and how to reduce them applying normalization methods previously developed. |
| Databáze: | OpenAIRE |
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