Elemental iron does repress transferrin, haemopexin and haemoglobin receptor expression in Haemophilusinfluenzae
| Autor: | Ann Smith, Paul Williams, J Holland, Abdulaziz A. Hasan |
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| Rok vydání: | 2006 |
| Předmět: |
Receptors
Peptide Receptor expression Down-Regulation Protoporphyrins Repressor Receptors Cell Surface Transferrin receptor Heme Biology Ferric Compounds Microbiology Hemoglobins chemistry.chemical_compound Chlorides Hemopexin Iron-Binding Proteins Receptors Transferrin Genetics Molecular Biology chemistry.chemical_classification Binding protein Transferrin Transferrin-Binding Proteins Haemophilus influenzae Culture Media Chemically defined medium chemistry Biochemistry Carrier Proteins |
| Zdroj: | FEMS Microbiology Letters. 150:19-26 |
| ISSN: | 0378-1097 |
| DOI: | 10.1111/j.1574-6968.1997.tb10344.x |
| Popis: | The iron repressible nature of Haemophilus influenzae transferrin binding proteins suggests a regulatory role for elemental iron in their expression. The existence of a Haemophilus ferric uptake repressor (Fur) binding motif identified in the promoter region of both tbpA and tbpB further supports this hypothesis. However, a recent study using brain heart infusion growth medium suggested that transferrin binding protein synthesis in H. influenzae was haem-rather than iron-regulated. The present study re-investigates this observation and using a chemically defined medium, we demonstrate that elemental iron haem or protoporphyrin IX can each regulate Haemophilus influenzae transferrin, haemopexin and haemoglobin receptor expression. |
| Databáze: | OpenAIRE |
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