Transgenerational impacts of oral probiotic administration in pregnant mice on offspring gut immune cells and colitis susceptibility

Autor: Yoshikiyo Okada, Nao Sugihara, Shin Nishii, Suguru Itoh, Akinori Mizoguchi, Rina Tanemoto, Kazuki Horiuchi, Akira Tomioka, Hiroyuki Nishimura, Masaaki Higashiyama, Kazuyuki Narimatsu, Chie Kurihara, Kengo Tomita, Soichiro Miura, Yoshikazu Tsuzuki, Ryota Hokari
Rok vydání: 2022
Předmět:
Zdroj: Journal of gastroenterology and hepatologyReferences.
ISSN: 1440-1746
Popis: The study of the impact of environmental factors during pregnancy on fetal development has so far been focused primarily on those negatively affecting human health; however, little is known about the effects of probiotic treatment during pregnancy on inflammatory bowel diseases (IBD). In this study, we investigated whether oral administration of heat-killed probiotics isolated from fermented foods decreased the vulnerability of offspring to IBD.Probiotics were administered to the pregnant mice until the birth of pups, after which the parent mice were maintained with autoclaved water. Partial pups were evaluated for dextran sodium sulfate-induced colitis. The influence of CD11cOral administration of heat-killed probiotics to pregnant dams significantly decreased inflammation induced by dextran sodium sulfate in pups. Probiotic treatment increased the number of CD103Oral administration of probiotics during gestation induced transgenerational immunomodulatory effects on the gut-associated immune system and resilience to experimental colitis in the offspring. Our results suggest that consumption of fermented foods during pregnancy can be effective in preventing inflammatory diseases such as IBD beyond generation.
Databáze: OpenAIRE