Sex differences in the phylum-level human gut microbiota composition
| Autor: | Vitaly Guryanov, Alexander Koliada, Nadiia Kryzhanovska, Mariana Romanenko, Alexander Vaiserman, Oleh Lushchak, Vladislav Moseiko |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Adult Male Gut microbiota composition Hormonal profile Adolescent Firmicutes Population Physiology Sex-specific differences Gut flora Microbiology Actinobacteria 03 medical and health sciences Young Adult Human gut Sex Factors Humans education Child Gonadal Steroid Hormones 030304 developmental biology Population Density 0303 health sciences education.field_of_study Firmicutes to Bacteroidetes ratio biology 030306 microbiology Phylum Research Bacteroidetes Middle Aged biology.organism_classification QR1-502 Gastrointestinal Microbiome Sexual dimorphism Female Ukraine |
| Zdroj: | BMC Microbiology BMC Microbiology, Vol 21, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1471-2180 |
| Popis: | Background Evidence was previously provided for sex-related differences in the human gut microbiota composition, and sex-specific discrepancy in hormonal profiles was proposed as a main determinant of these differences. On the basis of these findings, the assumption was made on the role of microbiota in the sexual dimorphism of human diseases. To date, sex differences in fecal microbiota were demonstrated primarily at lower taxonomic levels, whereas phylum-level differences between sexes were reported in few studies only. In the present population-based cross-sectional research, sex differences in the phylum-level human gut microbiota composition were identified in a large (total n = 2301) sample of relatively healthy individuals from Ukraine. Results Relative abundances of Firmicutes and Actinobacteria, as determined by qRT-PCR, were found to be significantly increased, while that of Bacteroidetes was significantly decreased in females compared to males. The Firmicutes to Bacteroidetes (F/B) ratio was significantly increased in females compared to males. Females had 31 % higher odds of having F/B ratio more than 1 than males. This trend was evident in all age groups. The difference between sexes was even more pronounced in the elder individuals (50+): in this age group, female participants had 56 % higher odds of having F/B ratio > 1 than the male ones. Conclusions In conclusion, sex-specific differences in the phylum-level intestinal microbiota composition were observed in the Ukraine population. The F/B ratio was significantly increased in females compared to males. Further investigation is needed to draw strong conclusions regarding the mechanistic basis for sex-specific differences in the gut microbiota composition and regarding the role of these differences in the initiation and progression of human chronic diseases. |
| Databáze: | OpenAIRE |
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