Prevalence of Age-Related Macular Degeneration in Europe
| Autor: | Johanna M. Colijn, Gabriëlle H.S. Buitendijk, Elena Prokofyeva, Dalila Alves, Maria L. Cachulo, Anthony P. Khawaja, Audrey Cougnard-Gregoire, Bénédicte M.J. Merle, Christina Korb, Maja G. Erke, Alain Bron, Eleftherios Anastasopoulos, Magda A. Meester-Smoor, Tatiana Segato, Stefano Piermarocchi, Paulus T.V.M. de Jong, Johannes R. Vingerling, Fotis Topouzis, Catherine Creuzot-Garcher, Geir Bertelsen, Norbert Pfeiffer, Astrid E. Fletcher, Paul J. Foster, Rufino Silva, Jean-François Korobelnik, Cécile Delcourt, Caroline C.W. Klaver, Soufiane Ajana, Blanca Arango-Gonzalez, Verena Arndt, Vaibhav Bhatia, Shomi S. Bhattacharya, Marc Biarnés, Anna Borrell, Sebastian Bühren, Sofia M. Calado, Audrey Cougnard-Grégoire, Sascha Dammeier, Eiko K. de Jong, Berta De la Cerda, Anneke I. den Hollander, Francisco J. Diaz-Corrales, Sigrid Diether, Eszter Emri, Tanja Endermann, Lucia L. Ferraro, Míriam Garcia, Thomas J. Heesterbeek, Sabina Honisch, Carel B. Hoyng, Eveline Kersten, Ellen Kilger, Hanno Langen, Imre Lengyel, Phil Luthert, Cyrille Maugeais, Magda Meester-Smoor, Jordi Monés, Everson Nogoceke, Tunde Peto, Frances M. Pool, Eduardo Rodríguez, Marius Ueffing, Karl U. Ulrich Bartz-Schmidt, Elisabeth M. van Leeuwen, Timo Verzijden, Markus Zumbansen, Niyazi Acar, Eleftherios Anastosopoulos, Augusto Azuara-Blanco, Arthur Bergen, Christine Binquet, Alan Bird, Lionel Brétillon, Gabrielle Buitendijk, Maria Luz Cachulo, Usha Chakravarthy, Michelle Chan, Petrus Chang, Johanna Colijn, Philippa Cumberland, José Cunha-Vaz, Vincent Daien, Gabor Deak, Marie-Noëlle Delyfer, Anneke den Hollander, Martha Dietzel, Maja Gran Erke, Sascha Fauser, Robert Finger, Astrid Fletcher, Paul Foster, Panayiota Founti, Arno Göbel, Theo Gorgels, Jakob Grauslund, Franz Grus, Christopher Hammond, Catherine Helmer, Hans-Werner Hense, Manuel Hermann, René Hoehn, Ruth Hogg, Frank Holz, Carel Hoyng, Nomdo Jansonius, Sarah Janssen, Anthony Khawaja, Caroline Klaver, Julia Lamparter, Mélanie Le Goff, Sergio Leal, Yara Lechanteur, Terho Lehtimäki, Andrew Lotery, Irene Leung, Matthias Mauschitz, Bénédicte Merle, Verena Meyer zu Westrup, Edoardo Midena, Stefania Miotto, Alireza Mirshahi, Sadek Mohan-Saïd, Michael Mueller, Alyson Muldrew, Sandrina Nunes, Konrad Oexle, Jugnoo Rahi, Olli Raitakari, Luisa Ribeiro, Marie-Bénédicte Rougier, José Sahel, Aggeliki Salonikiou, Clarisa Sanchez, Steffen Schmitz-Valckenberg, Cédric Schweitzer, Jasmin Shehata, Giuliana Silvestri, Christian Simader, Eric Souied, Henriet Springelkamp, Robyn Tapp, Virginie Verhoeven, Therese Von Hanno, Stela Vujosevic, Katie Williams, Christian Wolfram, Jennifer Yip, Jennyfer Zerbib, Isabella Zwiener |
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| Přispěvatelé: | Erasmus University Rotterdam, Scientific Institute for Public Health, Federal Agency for Medicines and Health Products, Partenaires INRAE, Association for Innovation and Biomedical Research on Light and Image (AIBILI), Universidade de Coimbra, Coimbra University Hospital (CHUC), University of Cambridge [UK] (CAM), Moorfields Eye Hospital NHS Foundation Trust, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux (UB), Mainz University Medical Center, Oslo University Hospital [Oslo], Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Department of Ophthalmology, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Aristotle University of Thessaloniki, Universitad de Padua, Univ Padua, Dept Ophthalmol, Padua, Italy, Royal Netherlands Academy of Arts and Sciences (KNAW), University Hospital of North Norway [Tromsø] (UNN), London School of Hygiene and Tropical Medicine (LSHTM), Institute of Ophthalmology, University of Messina, CHU Bordeaux [Bordeaux], Radboud University Medical Center [Nijmegen], The European Eye Epidemiology (E3) Consortium, Epidemiology, Ophthalmology, Erasmus MC other, Other departments, ANS - Complex Trait Genetics, Human Genetics, Genome Analysis |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Visual acuity OPTICAL COHERENCE TOMOGRAPHY MACULOPATHY genetic structures Population Prevalence HEART-DISEASE choroidal neovascularization Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] 03 medical and health sciences Rotterdam Study 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center BEAVER DAM EYE Epidemiology geographic atrophy medicine VISUAL IMPAIRMENT [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs education POPULATION education.field_of_study BIRTH COHORT business.industry Macular degeneration medicine.disease TRENDS Confidence interval eye diseases 3. Good health European Prospective Investigation into Cancer and Nutrition Ophthalmology 030104 developmental biology Age-related Macular Degeneration ENDOTHELIAL GROWTH-FACTOR BLINDNESS 030221 ophthalmology & optometry Optometry Age-related Macular Degeneration choroidal neovascularization geographic atrophy sense organs medicine.symptom business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Demography |
| Zdroj: | Ophthalmology, 124, 1753-1763 Ophthalmology Ophthalmology: Journal of The American Academy of Ophthalmology, 124(12), 1753-1763 Ophthalmology: Journal of The American Academy of Ophthalmology Ophthalmology: Journal of The American Academy of Ophthalmology, Elsevier, 2017, 124 (12), pp.1753-1763. ⟨10.1016/j.ophtha.2017.05.035⟩ Ophthalmology, 124(12), 1753-1763. Elsevier Inc. Ophthalmology, 124, 12, pp. 1753-1763 |
| ISSN: | 0161-6420 |
| Popis: | Manuscript no. 2016-1147 Supplemental material is available at www.aaojournal.org/; International audience; [u]Purpose:[/u] Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future. [u]Design:[/u] Meta-analysis of prevalence data. [u]Participants:[/u] A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe. [u]Methods:[/u] AMD was diagnosed based on fundus photographs using the Rotterdam Classification. Prevalence of early and late AMD was calculated using random-effects meta-analysis stratified for age, birth cohort, gender, geographic region, and time period of the study. Best-corrected visual acuity (BCVA) was compared between late AMD subtypes; geographic atrophy (GA) and choroidal neovascularization (CNV). [u]Main Outcome Measures:[/u] Prevalence of early and late AMD, BCVA, and number of AMD cases. [u]Results:[/u] Prevalence of early AMD increased from 3.5% (95% confidence interval [CI] 2.1% -5.0%) in those aged 55-59 years to 17.6% (95% CI 13.6%-21.5%) in those aged >= 85 years; for late AMD these figures were 0.1% (95% CI 0.04%-0.3%) and 9.8% (95% CI 6.3%-13.3%), respectively. We observed a decreasing prevalence of late AMD after 2006, which became most prominent after age 70. Prevalences were similar for gender across all age groups except for late AMD in the oldest age category, and a trend was found showing a higher prevalence of CNV in Northern Europe. After 2006, fewer eyes and fewer >= 80-year-old subjects with CNV were visually impaired (P = 0.016). Projections of AMD showed an almost doubling of affected persons despite a decreasing prevalence. By 2040, the number of individuals in Europe with early AMD will range between 14.9 and 21.5 million, and for late AMD between 3.9 and 4.8 million. [u]Conclusion:[/u] We observed a decreasing prevalence of AMD and an improvement in visual acuity in CNV occuring over the past 2 decades in Europe. Healthier lifestyles and implementation of anti-vascular endothelial growth factor treatment are the most likely explanations. Nevertheless, the numbers of affected subjects will increase considerably in the next 2 decades. AMD continues to remain a significant public health problem among Europeans. |
| Databáze: | OpenAIRE |
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