Oxidative stress induced in Hyalella azteca by an effluent from a NSAID-manufacturing plant in Mexico

Autor: Karen Adriana Novoa-Luna, Rubí Romero-Romero, Leobardo Manuel Gómez-Oliván, Sandra García-Medina, Marcela Galar-Martínez, Catalina Martínez-Vieyra, Reyna Natividad-Rangel, Nadia Neri-Cruz, Nely SanJuan-Reyes
Rok vydání: 2016
Předmět:
0301 basic medicine
Antioxidant
Health
Toxicology and Mutagenesis
medicine.medical_treatment
010501 environmental sciences
Management
Monitoring
Policy and Law
Wastewater
Toxicology
medicine.disease_cause
01 natural sciences
Superoxide dismutase
Lipid peroxidation
Protein Carbonylation
03 medical and health sciences
chemistry.chemical_compound
Manufacturing and Industrial Facilities
medicine
Animals
Amphipoda
Food science
Mexico
0105 earth and related environmental sciences
chemistry.chemical_classification
Glutathione Peroxidase
biology
Superoxide Dismutase
Glutathione peroxidase
Anti-Inflammatory Agents
Non-Steroidal
Hyalella azteca
General Medicine
biology.organism_classification
Catalase
Lowest-observed-adverse-effect level
Oxidative Stress
030104 developmental biology
chemistry
biology.protein
Lipid Peroxidation
Oxidative stress
Biomarkers
Water Pollutants
Chemical
Environmental Monitoring
Zdroj: Ecotoxicology (London, England). 25(7)
ISSN: 1573-3017
Popis: Production in the pharmaceutical industry has increased and along with it, the amount of wastewater of various characteristics and contaminant concentrations. The main chemicals in these effluents are solvents, detergents, disinfectants—such as sodium hypochlorite (NaClO)—and pharmaceutical products, all of which are potentially ecotoxic. Therefore, this study aimed to evaluate the oxidative stress induced in the amphipod Hyalella azteca by the effluent from a nonsteroidal anti-inflammatory drug (NSAID)-manufacturing plant. The median lethal concentration (72 h-LC50) was determined and H. azteca were exposed to the lowest observed adverse effect level (0.0732 %) for 12, 24, 48 and 72 h, and biomarkers of oxidative stress were evaluated [hydroperoxide content (HPC), lipid peroxidation (LPX), protein carbonyl content (PCC), and the activity of the superoxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)]. Statistically significant increases with respect to the control group (P
Databáze: OpenAIRE
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